نتایج جستجو برای: آنزیم g6pd
تعداد نتایج: 13468 فیلتر نتایج به سال:
Introduction & Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common metabolic disease of red blood cells. It affects about 35 millions people in the entire world. Its incidence in IRAN is estimated to be 10-14.9%. Transfusion of G6PD deficient blood produces many untoward side effects in recipients. Despite the high incidence of the disease and such risks, blood don...
Glucose-6-phosphate dehydrogenase (G6PD) supports cellular antioxidant pathways. G6PD deficiency is associated with malaria protection but was shown to worsen the clinical course to injury. This study tested whether G6PD deficiency manifests in altered cytokine responses using peritoneal macrophages from a G6PD-deficient mouse model with a degree of defect similar to the common type A(-) human ...
BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that can result in red cell breakdown under oxidative stress when exposed to certain medicines including antimalarials. We evaluated the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) as a point-of-care tool for screening G6PD deficiency. METHODS A cross-sectional ...
چکیده مقدمه: نقص ﮋنتیکی آنزیم g6pd شایع ترین نقص آنزیمی در جهان است که گستره متفاوتی در جمعیت های مختلف دارد و شیوع آن از 1/0 تا 50 درصد متفاوت است. پیامد بالینی آن از جمله آنمی همولی تیک حاد و یرقان نوزادی در مناطقی که عوامل اکسیدان مثل لوبیای fava وجود دارد بیشتر بروز می کند. هدف: بررسی شیوع این نقص درمرکز استان گیلان به عنوان یکی از مناطق شایع مصرف لوبیای fava. مواد و روش ها: در مطالعه ای مق...
Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant. G6PD deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. Here, we show that G6PD is negatively regulated by acetylation on lysine 403 (K4...
BACKGROUND Age-related skewing of X-chromosome inactivation leading to glucose-6-phosphate dehydrogenase (G6PD) deficiency in elderly women in a population with prevalent G6PD gene mutations was investigated. METHODS G6PD activity was measured biochemically. G6PD mutations were detected by polymerase chain reaction (PCR) and allele-specific extension, and analyzed by matrix-assisted laser des...
In order to explore the nature of glucose-6-phosphate dehydrogenase (G6PD) deficiency in one of the coastal provinces of the Caspian Sea (Mazandaran) in Iran, we have analysed the G6PD gene in 74 unrelated G6PD-deficient males (2-6 year children) with a history of Favism, by using PCR and subsequent digestion by appropriate restriction enzymes, looking for the presence of certain known mutation...
The primary recognized health risk from common deficiencies in glucose-6-phosphate dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis. Here we show that litters from untreated pregnant mutant mice with a hereditary G6PD deficiency had increased prenatal (fetal resorptions) and postnatal death. When treated with the anticonvulsant drug phenytoin, a hu...
BACKGROUND This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, in the western region of Thailand, an endemic region for malaria. METHODS Data about patients with malaria hospitalized between 2013 and 2015 were collected. Clinical and sociodemographic characteristics such as age a...
The primary metabolic defect in subjects susceptible to hemolysis by various drugs and fava beans is considered to be the low glucose-6-phosphate dehydrogenase (G6PD) activity in their red cells (1, 2). Such diminished enzymatic activity could be the end result of qualitative or quantitative changes in the enzyme as well as enzyme inhibition or lack of enzyme activation. However, studies on the...
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