Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. Monogenic forms of DCM are observed in families with mutations located mostly in genes encoding structural and sarcomeric proteins. However, strong evidence suggests that genetic factors also affect the susceptibility to idiopathic DCM. To identify risk alleles for non-familial forms of DCM, we carried ou...

Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to morbidity and mortality, it is rapidly increasing menace worldwide. Less attention has been paid to alert prediabetics through determining the comprehensive predictors of diabetic cardiomyopathy (DCM) and ameliorating DCM using novel approaches. DCM is recognized as asympt...

Pregnancy in dilated cardiomyopathy (DCM) has an extremely high risk. However, DCM is usually asymptomatic at a young age. In pregnancy with DCM, it appears progressive and becomes symptomatic. mimicking peripartum (PPCM). We reported case of 23-year-old woman who was 20 weeks pregnant her first child complained chest palpitations severe faintness. These symptoms have happened started during pr...

The purpose of this study was to compare the echocardiographic features of Irish wolfhounds with clinically inapparent dilated cardiomyopathy (DCM) (n = 33) to dogs with advanced DCM (n = 33) and to normal dogs (n = 262). Significant differences were detected between the three groups. In dogs with DCM, the most sensitive diagnostic measurements were: end-systolic volume index (ESVI), E-point to...

DCM (Discrete Choice Models) is a package, written in Ox, for estimating a class of discrete choice models. DCM represents an important development for both the OxMetric and, more generally, microeconometric computing environment in making available a broad range of discrete choice models, including standard binary response models, with notable extensions including conditional mixed logit, mixe...

According to divine-command metaethics (DCM), whatever is morally good or right has that status because, and only because, it conforms to God:� will. I argue that DCM is false or vacuous: either DCM is false, or else there are no instantiated moral properties, and no moral truths, to which DCM can even apply. The sort of criticism I offer is familiar, but I develop it in what I believe is a nov...

AIMS To determine whether the extent of myocardial fibrosis by late-gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR), and echocardiographic ventricular dyssynchrony are independently associated with response to medical therapy in patients with newly diagnosed idiopathic dilated cardiomyopathy (DCM). Myocardial fibrosis and ventricular dyssynchrony are frequent findings in DCM....

The development of large-scale network models that infer the effective (directed) connectivity among neuronal populations from neuroimaging data represents a key challenge for computational neuroscience. Dynamic causal models (DCMs) of neuroimaging and electrophysiological data are frequently used for inferring effective connectivity but are presently restricted to small graphs (typically up to...

In majority of the cases familial dilated cardiomyopathy (DCM) is inherited in an autosomal dominant manner. In rare instances, this condition is inherited in an autosomal recessive pattern. In other rare cases, DCM can be inherited in an Xlinked pattern. Establishing a genetic diagnosis confirms or modifies the clinical diagnosis and enables disease specific estimates on prognostics and treatm...