Integrin-ligand interactions are regulated in a complex manner by divalent cations, and previous studies have identified ligand-competent, stimulatory, and inhibitory cation-binding sites. In collagen-binding integrins, such as 2 1, ligand recognition takes place exclusively at the subunit I domain. However, activation of the I domain depends on its interactionwith a structurally similar domain...

Midas cichlid fish are a Central American species flock containing 13 described species that has been dated to only a few thousand years old, a historical timescale infrequently associated with speciation. Their radiation involved the colonization of several clear water crater lakes from two turbid great lakes. Therefore, Midas cichlids have been subjected to widely varying photic conditions du...

BACKGROUND The study was designed to determine the validity and reliability of the Bahasa Melayu version (MIDAS-M) of the Migraine Disability Assessment (MIDAS) questionnaire. METHODS Patients having migraine for more than six months attending the Neurology Clinic, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia, were recruited. Standard forward and back translation proc...

زمینه و هدف: کشتی ورزشی برخوردی با انقباض‌های برون‌گرای مکرر شدت بالاست. چنین فعالیت‌هایی که شدید انجام می‌گیرد، اختلالات مکانیکی متابولیکی همراه است. بالایی از فعالیت در به‌طور چشمگیری به تولید ناگهانی گونه‌های اکسیژن واکنش‌پذیر بنیان‌های آزاد حین رقابت بازیافت پس هر مسابقه منجر می‌شود، به‌طوری‌که حتی ممکن است طی این دسته فعالیت‌ها، ذخیرة ضداکسایشی به‌شدت کاسته تخلیه شود به‌دنبال ناکارامدی دست...

This paper introduces cointegrating mixed data sampling (CoMiDaS) regressions, generalizing nonlinear MiDaS regressions in the extant literature. Under a linear mixed-frequency data-generating process, MiDaS regressions provide a parsimoniously parameterized nonlinear alternative when the linear forecasting model is over-parameterized and may be infeasible. In spite of potential correlation of ...

The dynein-related AAA ATPase Rea1 is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis. Using electron microscopy, we show that Rea1's motor domain is docked to the pre-60S particle and its tail-like structure, harboring a metal ion-dependent adhesion site (MIDAS), protrudes from the preribosome. Typically, integrins utilize a MIDAS to bind extracellular ...