نتایج جستجو برای: بهترین شیوههای مدیریت bmp

تعداد نتایج: 98086  

2017
Fang Shan YuJuan Liu Haiying Jiang Fei Tong

Here, we describe a bone morphogenetic protein-2 (BMP-2) nanocarrier based on glycyrrhetinic acid (GA)-poly(ethylene glycol) (PEG)-b-poly(l-lysine) (PLL). A protein nanocarrier was synthesized, characterized and evaluated as a BMP-2 delivery system. The designed nanocarrier was synthesized based on the ring-opening polymerization of amino acid N-carboxyanhydride. The final product was measured ...

2009
Helena Wensman Nils-Erik Heldin Gunnar Pejler Eva Hellmén

BACKGROUND BMPs are currently receiving attention for their role in tumorigenesis and tumor progression. Currently, most BMP expression studies are performed on carcinomas, and not much is known about the situation in sarcomas. METHODOLOGY/PRINCIPAL FINDINGS We have investigated the BMP expression profiles and Smad activation in clones from different spontaneous canine mammary tumors. Spindle...

Journal: :Current Biology 2013
Jackie Gavin-Smyth Yu-Chiun Wang Ian Butler Edwin L. Ferguson

To achieve the "constancy of the wild-type," the developing organism must be buffered against stochastic fluctuations and environmental perturbations. This phenotypic buffering has been theorized to arise from a variety of genetic mechanisms and is widely thought to be adaptive and essential for viability. In the Drosophila blastoderm embryo, staining with antibodies against the active, phospho...

Journal: :The Journal of biological chemistry 2003
Takatora Takada Takenobu Katagiri Michiyo Ifuku Naoko Morimura Makoto Kobayashi Kohji Hasegawa Akira Ogamo Ryutaro Kamijo

Bone morphogenetic proteins (BMPs), which have been shown to be heparin-binding proteins, induce osteoblast differentiation in mesenchymal cells. In the present study, we examined the effects of heparin on the BMP activities in C2C12 myoblasts. Heparin dose dependently enhanced the osteoblast differentiation induced by not only homodimers of BMP-2 or BMP-4 but also heterodimers of BMP-2/6 or BM...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2017
Heon-Woo Lee Diana C Chong Roxana Ola William P Dunworth Stryder Meadows Jun Ka Vesa M Kaartinen Yibing Qyang Ondine Cleaver Victoria L Bautch Anne Eichmann Suk-Won Jin

OBJECTIVE Increasing evidence suggests that bone morphogenetic protein (BMP) signaling regulates angiogenesis. Here, we aimed to define the function of BMP receptors in regulating early postnatal angiogenesis by analysis of inducible, endothelial-specific deletion of the BMP receptor components Bmpr2 (BMP type 2 receptor), Alk1 (activin receptor-like kinase 1), Alk2, and Alk3 in mouse retinal v...

Journal: :The Biochemical journal 2011
Chandi C Mandal Suthakar Ganapathy Yves Gorin Kalyankar Mahadev Karen Block Hanna E Abboud Stephen E Harris Goutam Ghosh-Choudhury Nandini Ghosh-Choudhury

BMP-2 (bone morphogenetic protein-2) promotes differentiation of osteoblast precursor cells to mature osteoblasts that form healthy bone. In the present study, we demonstrate a novel mechanism of BMP-2-induced osteoblast differentiation. The antioxidant NAC (N-acetyl-L-cysteine) and the flavoprotein enzyme NAD(P)H oxidase inhibitor DPI (diphenyleneiodonium) prevented BMP-2-stimulated alkaline p...

Journal: :Tissue engineering. Part A 2010
Huina Zhang Francesco Migneco Chia-Ying Lin Scott J Hollister

Poly(ε-caprolactone) (PCL) has received considerable attention in bone tissue engineering. However, the lack of osteoinductive ability of PCL limits its application. The aim of this study was to directly attach bone morphogenetic protein-2 (BMP-2) to PCL scaffolds by a crosslinking conjugation method and to investigate whether the bound BMP-2 maintained bioactivity in vitro. Immunofluorescent s...

Journal: :Journal of cell science 2009
Zhonghua Hu Chaochen Wang Ying Xiao Nengyin Sheng Yibin Chen Ye Xu Liang Zhang Wei Mo Naihe Jing Gengxi Hu

Heparan sulfate proteoglycans (HSPGs) are required for various signaling pathways, one of which is the bone morphogenetic protein (BMP) signaling pathway. N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSPGs, and is involved in bone and lung development. Here, we report that in spite of the redundant expression of Ndst2, Ndst3 and Ndst4 ge...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Anna Csiszar Nazar Labinskyy Kira E Smith Aracelie Rivera Erik N T P Bakker Hanjoong Jo Jason Gardner Zsuzsanna Orosz Zoltan Ungvari

OBJECTIVE Bone morphogenetic protein 4 (BMP-4) is a transforming growth factor beta family member cytokine that exerts proinflammatory effects on the endothelium and is likely to play a role in atherogenesis. Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown. METHODS AND RESULTS We fo...

Journal: :Glycobiology 2014
Qinglei Hang Ying Zhou Sicong Hou Dongmei Zhang Xiaojing Yang Jianping Chen Zhiyun Ben Chun Cheng Aiguo Shen

Bone morphogenetic protein-2 (BMP-2), a glycosylated protein, has been demonstrated to play a key role in osteoblast differentiation. However, the function of its glycosylation is incompletely understood. In this study, we examined the role that N-linked glycans (NLG) play in the secretion of BMP-2. Blocking the addition of NLGs or inhibiting initial glycan processing prevented the secretion of...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید