The cancer-immune interplay and its role on the evolution of NSCLC might be disclosed through detection local systemic cues. Aim: To determine whether peripheral blood (PB) immune profiles may mirror clinically relevant tumor microenvironmental (TIME) features in resected patients. Tissue PB samples were prospectively collected at surgery from 80 consecutive stage I-IIIA cases. immunohistochemi...

lymphocyte cd4 + count, a standard laboratory test for staging of hiv infection, is expensive and unavailable in resource-restricted countries. total lymphocyte count (tlc) and hemoglobin (hb) are recommended as simple & inexpensive surrogates. the aim of this study was to assess the correlation, sensitivity and predictive power of these parameters as substitutes for cd 4 count. one hundred hiv...

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...

The study included 24 patients, which formed the baseline group — 12 patients with pulmonary tuberculosis in combination COVID-19 infection and control tuberculosis. There were studied leukocyte formula, content of CD3, CD4, CD8 lymphocytes, NO2-+NO3- total its metabolites. obtained results showed that there is a pronounced decrease lymphocytes an unexpressed shift formula to left. lymphocyte d...

Background and Aim: Intrahepatic cholestasis of pregnancy (ICP) is associated with raised liver enzymes, pruritus elevated fasting total bile acids (TBA) may lead to adverse perinatal outcomes such as preterm birth, meconium-stained liquor, stillbirth, foetal growth restriction etc. The change in inflammatory profile ICP association TBA not known. Methods: Patients (aged >21) confirmed diagnosi...

current mainstay of treatment for human immunodeficiency virus (hiv)-infected patients is highly active antiretroviral therapy (haart) but little is known about the long-term clinical outcome for hiv-infected patients who have received haart. determining factors associated with longterm survival in the course of treatment may allow modification to be made for patients who are at a greater risk ...

cytokine production  in response to allergens may influence the development of atopy- predisposing immune responses, initializing the  early programming of  allergy and  asthma. vitamin d  intake  may be  protective  due  to  its  immunoregulatory properties,  that  may contribute  to  influence the expression of  the atopic phenotype  initiated in early life. the objective of our study was to ...