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G Johannsson A G Nilsson R Bergthorsdottir P Burman P Dahlqvist B Ekman B E Engström T Olsson O Ragnarsson M Ryberg J Wahlberg B M K Biller J P Monson P M Stewart H Lennernäs S Skrtic

CONTEXT Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile. OBJECTIVE The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) do...

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Clearance of technetium-99m-DTPA and HRCT findings in the evaluation of patients with Idiopathic Pulmonary Fibrosis

Journal: :BMC Pulmonary Medicine 2006

Katerina M Antoniou Katerina Malagari Nikolaos Tzanakis Kostas Perisinakis Emmanouil K Symvoulakis Nikolaos Karkavitsas Nikolaos M Siafakas Demosthenes Bouros

BACKGROUND Clearance of inhaled technetium-labeled diethylenetriamine pentaacetate (99mTc-DTPA) is a marker of epithelial damage and an index of lung epithelial permeability. The aim of this study was to investigate the role of 99mTc-DTPA scan in patients with Idiopathic Pulmonary Fibrosis (IPF). Our hypothesis is that the rate of pulmonary 99mTc-DTPA clearance could be associated with extent o...

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