The tie gene encodes a receptor tyrosine kinase that is expressed in the endothelium of blood vessels, particularly during embryonic development and angiogenesis in adults. We have cloned and characterized the mouse tie gene and isolated the human and mouse tie promoters. The promoter activities of human and mouse tie were analyzed using luciferase reporter gene constructs in transfected cell l...

Here we present an antenna-integrated QCL which can be actively and optically modulated using light in the near infrared, creating an optical nanocircuit – coupling two different frequency antennas with a nonlinear active switching element. For our design, we chose two cross-polarized bow-tie antennas with an aligned central spot. We have used detailed FDTD simulations to choose the length of e...

Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.

liquid-liquid equilibrium data for the (water + lactic acid + 2-ethy-1-hexanol) ternary system in t=298.2k and p=1atm were determined and tie- lines related to equilibrium data has been drawn in the phases diagram . the reliability of the experimental tie-line data for this system was as confirmed by using the hand and othmer –tobias correlations. the tie-line data were correlated by means of t...

Diabetes is associated with impairment of angiogenesis such as reduction of myocardial capillary formation. Our previous studies demonstrate that disruption of Angiopoietin-1 (Ang-1)/Tie-2 signaling pathway contributes to the diabetes-associated impairment of angiogenesis. Protein tyrosine phosphatase (PTP) has a critical role in the regulation of insulin signal by inhibition of tyrosine kinase...

For canonical lipid raft mixtures of cholesterol (chol), N-palmitoylsphingomyelin (PSM), and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC), electron paramagnetic resonance (EPR) of spin-labeled phospholipids--which is insensitive to domain size--is used to determine the ternary phase diagram at 23°C. No phase boundaries are found for binary POPC/chol mixtures, nor for ternary mixtures with PSM...

BACKGROUND Curative resection of sigmoid colon and rectal cancer includes "high tie" of the inferior mesenteric artery (IMA). However, IMA ligation compromises blood flow to the anastomosis, which may increase the leakage rate, and it is unclear whether this confers a survival advantage. Accordingly, the IMA may be ligated at a point just below the origin of the left colic artery (LCA) "low tie...

We extend the existing enumeration of neck tie knots to include tie knots with a textured front, tied with the narrow end of a tie. These tie knots have gained popularity in recent years, based on reconstructions of a costume detail from The Matrix Reloaded, and are explicitly ruled out in the enumeration by Fink and Mao (2000). We show that the relaxed tie knot description language that compre...

Case 1 A 6 year old boy presented after his older brother had put a non-releasing garden tie around his neck during unsupervised play in the garden. He was unable to release the tie and in his attempt to do so, pulled it tighter. Fortunately, his grandmother was quick to respond and cut the tie oV with kitchen scissors. On examination, he had petechiae over his face but neither neck swelling or...