New millimeter-wave CO and HCN observations of the host galaxies of infrared-excess Palomar Green quasi-stellar objects (PG QSOs) previously detected in CO are presented. These observations are designed to assess the validity of using the infrared luminosity to estimate star formation rates of luminous AGN by determining the relative significance of dust-heating by young, massive stars and acti...

We present a HCN climatology of the years 2002– 2012, derived from FTIR limb emission spectra measured with the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) on the ENVISAT satellite, with the main focus on biomass burning signatures in the upper troposphere and lower stratosphere. HCN is an almost unambiguous tracer of biomass burning with a tropospheric lifetime of 5–6 mon...

Using one-dimensional thermochemical/photochemical kinetics and transport models, we examine the chemistry of nitrogen-bearing species in the Jovian troposphere in an attempt to explain the low observational upper limit for HCN. We track the dominant mechanisms for interconversion of N2-NH3 and HCN-NH3 in the deep, high-temperature troposphere and predict the rate-limiting step for the quenchin...

By combining molecular biological, electrophysiological, immunological, and computer modeling techniques, we here demonstrate a counterbalancing contribution of TASK channels, underlying hyperpolarizing K+ leak currents, and HCN channels, underlying depolarizing Ih, to the resting membrane potential of thalamocortical relay (TC) neurons. RT-PCR experiments revealed the expression of TASK1, TASK...

Hyperpolarization-activated cyclic nucleotide-gated "HCN" channels, which underlie the hyperpolarization-activated current (Ih), have been proposed to play diverse roles in neurons. The presynaptic HCN channel is thought to both promote and inhibit neurotransmitter release from synapses, depending upon its interactions with other presynaptic ion channels. In larvae of Drosophila melanogaster, i...

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in brain and heart. HCN channels are principally activated by membrane hyperpolarization and binding of cAMP. Here, we identify tyrosine phosphorylation by Src kinase as another mechanism affecting channel...

Cloud storage system poses new challenges to the community to support efficient concurrent querying tasks for various data-intensive applications, where indexes always hold important positions. A practical method is proposed to construct a two-layer indexing scheme for multi-dimensional data in diverse server-centric cloud storage system. RT-HCN is proposed, which is an indexing scheme integrat...

Ion channels play a major role in the regulation of T cell function in health and disease. In a computer-based model, established to simulate T cells’ membrane potential (VM) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. The predicted VM was more hyperpolarized than the measured VM, indicating that a yet unknown, depolarizing ion current might ...

We present radio observations of comet 9P/Tempel 1 associated with the Deep Impact spacecraft collision of 2005 July 4. Weak 18-cm OH emission was detected with the Parkes 64-m telescope, in data averaged over July 4 to 6, at a level of 12± 3 mJy km/s, corresponding to OH production rate 2.8 × 10 molecules/second (Despois et al. inversion model, or 1.0× 10 /s for the Schleicher & A’Hearn model)...

We report deep K-band (18-27GHz) observations with the 100-m Green Bank Telescope of HCN(1 − 0) line emission towards the two submillimeterselected galaxies (SMGs) SMMJ02399−0136 (z = 2.81) and SMMJ16359+6612 (z = 2.52). For both sources we have obtained spectra with channel-to-channel rms noise of σ ≤ 0.5mJy, resulting in velocity-integrated line fluxes better than < ∼ 0.1 Jy km s , although w...