OBJECTIVE To describe the prevalence of neurocognitive impairment (NCI) among early diagnosed and managed HIV-infected persons (HIV+) compared to HIV-negative controls. METHODS We performed a cross-sectional study among 200 HIV+ and 50 matched HIV-uninfected (HIV-) military beneficiaries. HIV+ patients were categorized as earlier (<6 years of HIV, no AIDS-defining conditions, and CD4 nadir >2...

PURPOSE To investigate mesothelin as a new target for immunotherapy in lung cancer. EXPERIMENTAL DESIGN Mesothelin mRNA and protein expression were assessed by reverse transcription-PCR, immunoblotting, and immunohistochemistry in human lung cancer specimens. Expression was also characterized in human lung cancer cell lines by flow cytometry and immunoblotting. The SS1P immunotoxin specific f...

BACKGROUND The worldwide elderly (≥ 65 years old) dialysis population has grown significantly. This population is expected to have more comorbid conditions and shorter life expectancies than the general elderly population. Predicting outcomes for this population is important for decision-making. Recently, a new comorbidity index (nCI) with good predictive value for patient outcomes was develope...

In this study, the human lung squamous carcinoma cell line NCI-H226 was transfected with the recombinant plasmid pBudCE4.1_Cx43 to explore the role of the Cx43 gene in cell growth, cell cycle, and tumor migration. pBudCE4.1-Cx43 was transfected into human lung squamous carcinoma NCI-H226 cells using Lipofectamine TM2000. The mRNA and protein expressions of Cx43 in the transfected cells were det...

Hippocampal precursor of nerve growth factor (proNGF)/NGF signaling occurs in conjunction with β-amyloid (Aβ) accumulations in Alzheimer disease (AD). To assess the involvement of this pathway in AD progression, we quantified these proteins and their downstream pathway activators in postmortem tissues from the brains of subjects with no cognitive impairment (NCI), mild cognitive impairment (MCI...

We present an analysis of current anticancer compounds that are in phase I, II, or III clinical trials and their structural analogues that have been screened in the National Cancer Institute (NCI) anticancer screening program. Bioactivity profiles, measured across the NCI 60 cell lines, were examined for a correspondence between the type of cancer proposed for clinical testing and selective sen...

هدف: آینده­ نگری مجموعه ­ای از توانایی­ های شناختی است. که شامل پیش­ بینی حالت­ ممکن آینده و نیازهای خود این مهارت برای برنامه­ ریزی، غلبه بر موانع رسیدن به موفقیت افراد کمک می­کند. یکی جدیدترین ابزارهای سنجش توانایی تفکر آینده­نگر در کودکان، مقیاس کودکان (مازاچووسکای مهی، 2020) است ویژگی­ روان­سنجی آن استفاده جمعیت ایرانی مورد مطالعه قرار نگرفته روش: روش پژوهش حاضر توصیفی مقطعی بود. تعداد 200 ...

Optimal RWIS network can be defined as an configuration where the total number of stations (RWIS density) are determined based on a well-established guideline and locations allocated systematically assuming that it will provide maximum monitoring coverage network. This paper examines quantifies benefit optimized how these benefits impact traffic safety. The methodological framework presented he...