نتایج جستجو برای: حلقه های sil
تعداد نتایج: 481048 فیلتر نتایج به سال:
Silymarin (SIL) is a flavonoid extracted from milk thistle seed that has been reported to decrease hyperglycemia in people with type 2 diabetes (T2D). However, it is not known whether SIL has direct secretory effects on β-cells. Using the β-cell line HIT-T15, SIL was shown to decrease intracellular peroxide levels and to augment glucose-stimulated insulin secretion (GSIS). However, the latter w...
Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed in patients with malignant lymphoma (ML). Therefore, sIL-2R is commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible for the increase in sIL-2R levels in patients with B-cell lymphomas have not yet been elucidated. We first hypothesized that lymphoma cells expressing IL-2R and some proteina...
The targeting of tumor cells by peptides for drug delivery is a promising strategy for cancer therapy. Interleukin-2 (IL-2), which mediates anti-tumor cellular immune responses, has been approved as a therapy for cancer. However, the serious side effects and short half-life of recombinant IL-2 (rIL-2) has limited its use clinically. Somatostatin receptors (SSTRs), which are expressed in a large...
INTRODUCTION Iran is one of the endemic regions with high prevalence of brucellosis. Several serological markers for diagnosis and response to treatment are available. Serum level of Soluble Interleukin-2 Receptor alpha (SIL-2Ralpha) is a new marker to assess response to therapy and clinical relapse of brucellosis. This study intends to investigate the serum levels of SIL-2Ralpha before and aft...
To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured physiologic parameters, including provocation concentration of histamine require...
Activation of T lymphocytes leads to the expression of interleukin-2 receptors (IL-2R) on the cell surface (1) as well as the release of soluble IL-2R (sIL-2R) molecules into the circulation (2). T lymphocytes are the predominant IL-2R bearing cells (3) and hence serum sIL-2R level provides a satisfactory indicator of T-cell activation in vivo. Elevated serum levels of sIL-2R have been reported...
We propose and discuss a complete sequent calculus formulation for Signed Interval Logic (SIL) with the chief purpose of improving proof support for SIL in practice. The main theoretical result is a simple characterization of the limit between decidability and undecidability of quantifier-free SIL. We present a mechanization of SIL in the generic proof assistant Isabelle and consider techniques...
We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 healthy controls. We examined a possible association between the serum levels o...
IL-27 is a cytokine of the IL-12 family that plays a key role in the regulation of inflammatory and T cell responses. Its receptor is composed of IL-27Rα and gp130 and activates the STAT pathway. We show in this study, using an ELISA that we developed, that a naturally occurring soluble form of IL-27Rα (sIL-27Rα) is produced by human activated CD4(+) and CD8(+) T cells, B cells, myeloid cells, ...
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