Aims: The aim of this study is to investigate the role of miR-206 in propofol induced protective effects in cerebral ischemia/reperfusion injury and to explore its possible mechanism. Methods: Hypoxia/reoxygenation (H/R) model of mouse motoneuron-like cell line NSC-43 was established, and the expression miR-206 upon propofol treatment was analyzed by Realtime PCR. Cells were transfected with mi...

James C. McWilliams Department of Atmospheric Sciences and Institute of Geophysics and Planetary Physics University of California, Los Angeles Los Angeles, CA 90095-1565 Phone:(310)206-2829 Fax:(310)206-5219 Email:[email protected] Alexander Shchepetkin Institute of Geophysics and Planetary Physics University of California, Los Angeles Los Angeles, CA 90095-1567 Phone:(310)206-9381 Fax:(310)20...

Aspartame is a phenylalanine containing sweetener, added to foods and drinks, which avoided in phenylketonuria (PKU). However, the amount of provided by aspartame unidentifiable from food drinks labels. We performed cross-sectional online survey aiming examine accidental consumption PKU. 206 questionnaires (58% female) were completed. 55% respondents (n = 114) adults with PKU or their parent/ca...

MicroRNAs (miRNAs) have been investigated widely as key regulators of gene expression in different diseases by affecting the miRNA‑mediated regulatory function. Human enterovirus 71 (HEV71) can cause a series of human diseases, including encephalitis. Chemokine (C‑C motif) ligand 2 (CCL2) is one of the important genes involved in regulating inflammation. However, the mechanisms underlying HEV71...

Epidermal growth factor (EGF) receptor (EGFR)/MAPK signaling can induce a switch in MCF-7 breast cancer cells, from an estrogen receptor (ER) -positive, Luminal-A phenotype, to an ER negative, Basal-like phenotype. Although mechanisms for this switch remain obscure, Basal-like cancers are typically high grade and confer a poorer clinical prognosis. We previously reported that miR-206 and ER rep...

Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of mRNAs. This study examined whether miR-206, previously shown to be elevated in estrogen receptor (ER) -negative breast cancer, regulates the expression of ER . Two putative miR-206 sites, (hER 1 and hER 2), were found in silico within the 3 -untranslated region of human ER mRNA. Transfection of MCF-7 cells w...

MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an apparent decreasing trend after induction, and sustained low expression througho...

miRNAs have been widely investigated in terms of cell proliferation and differentiation. However, little is known about their effects on bird growth. Here we characterized the promoter of miR-206 in chicken and found that the preferable promoter was located in 1200 bp upstream of pri-miR-206. In this region, many key transcription factors, including MyoD, c-Myb, CEBPα/β, AP-4, RAP1, Brn2, GATA-...

Glucose homeostasis is a complex indispensable process, and its dysregulation causes hyperglycemia and type 2 diabetes mellitus. Glucokinase (GK) takes a central role in these pathways and is thus rate limiting for glucose-stimulated insulin secretion (GSIS) from pancreatic islets. Several reports have described the transcriptional regulation of Gck mRNA, whereas its posttranscriptional mechani...