The nonsteroidal anti-inflammatory drug sulindac is known to inhibit chemical carcinogenesis in rodent models and cause regression of adenomas in patients with adenomatous polyposis coli. Sulindac is a prodrug that is metabolized to a pharmacologically active sulfide derivative that potently inhibits prostaglandin synthesis. Recent studies, however, have shown that a sulfone derivative of sulin...

Copyright: © 2016 Polo F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the clinical practice, therapeutic drug monitoring (TDM) concerns the analytical determination of pharmaceutical drug concent...

Neuroblastoma is the most common extracranial tumor in childhood. Outcome of stage 4 disease remains poor and the development of novel therapeutic approaches is thus urgently needed. Taurolidine (TRD), originally invented to avoid catheter infections, has shown to exhibit antineoplastic activity in various cancers. The growth of neuroblastoma cell lines is inhibited by TRD as recently demonstra...

The development of efficacious antitumor compounds with minimal toxicity is a hot research topic. Numerous cancer cell targeted agents are evaluated daily in laboratories for their antitumorigenicity at the pre-clinical level, but the process of their introduction into the market is costly and time-consuming. More importantly, even if these new antitumor agents manage to gain approval, clinicia...

DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and...

BACKGROUND To evaluate off-label and off-NCCN guidelines uses of antineoplastic drugs in a major Chinese hospital. METHODS Totally 1122 patients were selected from July to December 2011. Then, the off-label and off-NCCN guidelines uses of antineoplastic drugs were analyzed. RESULTS In 798 of 1122 patients (71.12%), drugs were used for off-label. In 317 of 1122 patients (28.25%), the drugs w...

INTRODUCTION: Various endogenous and exogenous processes contribute to the production of oxidative stress, which anticancer drugs may be one. This study aimed at evaluating effect breast cancer chemotherapy on stress. MATERIAL AND METHODS: Oxidative markers antioxidant defense molecules were monitored in 59 women undergoing a year treatment for cancer. RESULTS: During treatment, levels vitamin ...

platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. the nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. we exa...