Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by cytosolic calcium (Ca(2+)) plays an essential role in their signaling function, but structural determinants and mechanisms responsible for the InsP(3)R1 regulation by Ca(2+) are poorly understood. Using DT40 cell expression system and Ca(2+) imaging assay, in our previous study we identified a critical role of E210...

The vocal tract resonances of trained soprano singers were measured while they sang a range of vowels softly at different pitches. The measurements were made by broad band acoustic excitation at the mouth, which allowed the resonances of the tract to be measured simultaneously with and independently from the harmonics of the voice. At low pitch, when the lowest resonance frequency R1 exceeded f...

Microtubule nucleation on the centrosome and the fungal equivalent, the spindle pole body (SPB), is activated at the onset of mitosis. We previously reported that mitotic extracts prepared from Xenopus unfertilized eggs convert the interphase SPB of fission yeast into a competent state for microtubule nucleation. In this study, we have purified an 85-kDa SPB activator from the extracts and iden...

In this paper, we give a short survey on discrete geometry on red and blue points in the plane, most of whose results were obtained in the past decade. We consider balanced subdivision problems, geometric graph problems, graph embedding problems, Gallai-type problems and others. 1 Notation and Definitions In this paper, we give a short survey on discrete geometry on red and blue points in the p...

Comparative analysis of development and survivorship of two geographically divergent populations of the Natal fruit fly Ceratitis rosa Karsch designated as Ceratitis rosa R1 and Ceratitis rosa R2 from Kenya and South Africa were studied at seven constant temperatures (10, 15, 20, 25, 30, 33, 35 °C). Temperature range for development and survival of both populations was 15-35 °C. The development...

OBJECTIVE This study evaluated the possibility of accelerated gadolinium accumulation in irradiated brain parenchyma where the blood-brain barrier was weakened. METHODS From January 2010 to June 2015, 44 patients with supratentorial glioblastoma were retrospectively identified who underwent pre- and post-radiation brain MR imaging, including R1 mapping. The mean dose of administered gadobutro...

OBJECTIVE To compare long-term outcome of R0 (negative margins) and R1 (positive margins) liver resections for colorectal liver metastases (CLM) treated by an aggressive approach combining chemotherapy and repeat surgery. SUMMARY BACKGROUND DATA Complete macroscopic resection with negative margins is the gold standard recommendation in the surgical treatment of CLM. However, due to vascular p...

The edge-to-edge repair (EtER) technique was introduced in 1991 to treat both mitral regurgitation (1) and tricuspid regurgitation (2) caused by complex valvular lesions. The method involves anchoring the free edge of the diseased leaflet to the corresponding edge of the opposing leaflet, just at the place of the regurgitant jet. When the middle sections of the leaflets are sutured, a ‘double-o...

1Department of Pediatrics (Cardiology), University of California, San Francisco, USA, 2Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, USA, 3Department of Cardiac Surgery, University Clinic of SchleswigHolstein, Campus Lübeck, Lübeck, Germany, 4Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, USA, 5Department of Med...

The corticotropin-releasing factor (CRF) family is involved in modulating gastrointestinal motility, sensitivity and inflammation. CRF signalling exerts an important role in inflammatory bowel disease (IBD), predominantly by activating CRF receptors. The aim of the present study was to investigate the function of CRF receptor 1 (CRF‑R1) in the development of mucosal inflammation induced by dext...