Coexistence of thalassemia, hemoglobinopathies and malaria has interested geneticists over many decades. The present study represents such a population from the eastern Indian state of Orissa. Children and their siblings (n=38) were genotyped for β-thalassemia mutations and genotype-phenotype correlation was determined. The major genotype was IVS 1.5 mutation: 26% homozygous (n=10) and 37% (n=1...

https://doi.org/10.4068/cmj.2018.54.1.74 C Chonnam Medical Journal, 2018 Chonnam Med J 2018;54:74-75 Corresponding Author: Jong Chun Park Department of Cardiology, Chonnam National University Hospital, 42 Jaebong-ro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-6246, Fax: +82-62-223-3105, E-mail: [email protected] Article History: Received November 19, 2017 Revised November 26, 2017 Accepted De...

A new approach for the electro-thermal modeling of LDMOSFETs for power-amplifier design that bypasses pulsed-IVs and pulsed-RF measurements is presented in this paper. The existence of low-frequency dispersion in LDMOSFETs is demonstrated by comparing pulsed IVs with iso-thermal IVs. The modeling technique uses iso-thermal IV and microwave measurements to obtain the temperature dependence of sm...

Instrumental variable (IV) strategies are commonly used in political science to establish causal relationships, yet the identifying assumptions required by an IV design demanding and it remains challenging for researchers evaluate their plausibility. We replicate 61 papers published three top journals from past decade (2011-2020) document several troubling patterns: (1) often miscalculate first...

By application of modern recombinant DNA technology, especially the polymerase chain reaction (PCR)/dot-blot hybridization techniques, we have investigated the molecular basis of β-thalassemia from four different regions of Iran: central, south-east, south and north. In this study, the DNA samples were isolated from patients and for the identification of the mutations, the 6 oligonucleotide...

PURPOSE Identification of molecular characteristics of spontaneously regressing stage IVS and progressing stage IV neuroblastoma to improve discrimination of patients with metastatic disease following favorable and unfavorable clinical courses. EXPERIMENTAL DESIGN Serial analysis of gene expression profiles were generated from five stage IVS and three stage IV neuroblastoma. Differential expr...

BACKGROUND Hypertrophic cardiomyopathy (HCM), the most common genetic heart disease, is characterized by heterogeneous phenotypic expression. Body mass index has been associated with LV mass and heart failure symptoms in HCM. The aim of our study was to investigate whether regional (trunk, appendicular, epicardial) fat distribution and extent could be related to hypertrophy severity and pattern...

Subspace-based methods for state-space system identiication have lately been suggested as an alternative to more traditional techniques for multivariable system identiication. In this paper a novel instrumental variable (IV) approach to subspace-based system identiication is presented. Consistency and choices of IVs are discussed. One result of the paper is that the so-called PO-MOESP algorithm...

The mutation spectrum of 175 β-thalassemia (β-thal) carriers, identified in pilot carrier screening on 22,713 individuals from Balearic Islands (Spain), is reported. The β(0) CD39 (C>T) mutation is the most frequent (61.1%), followed by β(+) IVS-I-110 (G>A) (12.0%), β(+) IVS-I-6 (T>C) and β(0) IVS-1-1 (G>A) (3.4% both) and eight other rare mutations (2.9-0.6%); with a distinct prevalence and di...

AIMS Pulmonary atresia with intact ventricular septum (PA-IVS) is a complex congenital heart malformation with multitude therapeutic approaches. Recently, balloon valvotomy has been used as an alternative to primary surgery. This study aimed to identify echocardiographic markers of balloon dilation success in PA-IVS. METHODS AND RESULTS The echocardiograms of 26 patients diagnosed with PA-IVS...