(1993). Weighted averaging partial least squares regression (WA-PLS): definition and comparison with other methods for species-environment calibration. ABSTRACT A multivariate calibration method is proposed that relates to correspondence analysis as partial least squares (PLS) relates to principal components analysis. The new method extends and improves the weighted averaging (WA) method for in...

Cinobufagin (CB), a major bioactive component of the traditional Chinese medicine Chansu, has been reported to have potent antitumor activity. In this study, in vitro metabolism of CB among species was compared with respect to metabolic profiles, enzymes involved, and catalytic efficiency by using liver microsomes from human (HLM), mouse (MLM), rat (RLM), dog (DLM), minipig (PLM), and monkey (C...

To clarify the intestinal absorption pathway of medium-chain fatty acids from MLM-type structured triacylglycerols containing both medium- and long-chain fatty acids, we studied the lymphatic transport of 1,3-dioctanoyl-2-linoleoyl-sn-glycerol (8:0/18:2/8:0), 1,3-didecanoyl-2-linoleoyl-sn-glycerol (10:0/18:2/10:0), and 1,3-didodecanoyl-2-linoleoyl-sn-glycerol (12:0/18:2/12:0) in a rat model. Sa...

Automated image processing aids in classification of biological images. Many natural structures such as neurons may be multifractal and therefore not analyzable using current methods. The multifractal spectrum proposed here may mitigate this, Here we report the outcome of applying three methods that elucidate the variation within 16 rat retinal ganglion cells using the local connected fractal d...

OBJECTIVES To investigate the association between pain and functional independence in older adults during and after admission to rehabilitation after an acute illness or injury. DESIGN Prospective, observational cohort study. SETTING One community and one Veterans Affairs rehabilitation center. PARTICIPANTS Individuals aged 65 and older admitted for rehabilitation after an acute illness o...

The polysaccharide capsule of Streptococcus pneumoniae defines over ninety serotypes, which differ in their carriage prevalence and invasiveness for poorly understood reasons. Recently, an inverse correlation between carriage prevalence and oligosaccharide structure of a given capsule has been described. Our previous work suggested a link between serotype and growth in vitro. Here we investigat...

Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60-80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths. An in vivo pre-clinical model for these invasive cancers is necessary for testing new therapies. We characterize an immune competent recurrent/metastatic HPV+ murine model of...

Two different approaches are applied to quantify mixing in a shallow water model of the stratosphere. These are modified Lagrangian mean (MLM) theory and a technique referred to as ‘‘reverse domain filling with local gradient reversal’’ (RDF-LGR). The latter is similar to a previously existing technique using contour advection and contour surgery. It is first proved that in an inviscid shallow ...