Our study investigated the association between MMP-3 and MMP-8 single-nucleotide polymorphisms (SNPs) and alcohol-induced osteonecrosis of the femoral head (ONFH) in 695 Chinese males (299 cases and 396 control subjects). The minor allele of MMP-3 rs650108 was associated with a 0.78-fold decrease in alcohol-induced ONFH risk in the allelic model (95% CI = 0.63-0.97, P = 0.026). In the genetic m...

objective(s):to investigate the effects of local mild hypothermia on the expression of fas, fasl and mmp-3 after cerebral ischemia-reperfusion in rats. materials and methods:male wistar rats were divided into sham-operated group (sham), normothermia group (nt), and hypothermia group (ht). mcao/r model was established by longa’s method, and reperfusion was allowed after 2 hr occlusion. mild hypo...

Highlights . Elevated levels of matrix metalloproteinases 2 and 9 are associated with the initiation severity CHF developed after breast cancer therapy anthracyclines, which may contribute to cardiac remodeling progression systolic dysfunction. Concentrations metalloproteinases-2 -9 in blood serum serve as predictors unfavorable course anthracycline-induced heart failure. Aim To assess role (MM...

Background: Whilst ~40% of ACPA-negative RA-patients achieve sustained DMARD-free remission (SDFR; the absence synovitis after DMARD-cessation), biological pathways involved in SDFR-development are incompletely understood. Previously, high baseline levels MMP-3, SAA and CRP were found achieving SDFR. Differences biomarker might reflect distinct underlying leading towards disease resolution this...

In situ hydrogelation of injectable precursors upon biological stimulus is relevant to generate hydrogels under mild conditions and, potentially, at a side interest. Here, it shown that hydrolytic enzymes can be used initiate the formation covalent hydrogel networks, realizing cleavage-leading-to-gelation strategy. For this purpose, two-component system used, consisting 4-arm polyethylene glyco...

Background: Matrix metalloproteases (MMPs) are multi-chain proteins that regulated by tissue inhibitor of metalloproteinases (TIMP) and several other mechanisms. This Includes transcription regulation and protein form secretion. The roles of MMPs in wound healing and tissue repair. In tuberculosis (TB), the activity of MMPs is increased and TIMP inhibitors decrease activity. Therefore, in tuber...

Matrix metalloproteinase (MMP)-2 and MMP-9 are gelatinases that take part in several reproductive processes. The aim of this study was to measure levels MMP-2 fractionated stallion ejaculates, evaluate the association between these components semen quality, sperm longevity during cooled storage. Semen quality were assessed separately for sperm-rich fractions (HIGH), sperm-poor (LOW), whole ejac...

Sedum middendorffianum Maxim (SMM) is a Korean endemic plant belonging to the Crassulaceae family. This study aimed investigate antitumor effects of SMM extract on human ovarian cancer cells. Among five plants grown in Korea, showed most potent cytotoxicity cells and had little effect normal surface epithelial Furthermore, we revealed that dose-dependently induced apoptosis A2780 SKOV3 The mark...