The Asteroid Impact & Deflection Assessment (AIDA) mission will be the first space experiment to demonstrate asteroid impact hazard mitigation by using a kinetic impactor to deflect an asteroid. AIDA is an international cooperation, consisting of two mission elements: the NASA Double Asteroid Redirection Test (DART) mission and the ESA Asteroid Impact Mission (AIM) rendezvous mission. The prima...

Novel therapeutic strategies are needed for the treatment of hematologic malignancies; and bispecific antibody-derived molecules, such as dual-affinity re-targeting (DART) proteins, are being developed to redirect T cells to kill target cells expressing tumor or viral antigens. Here we present our findings of specific and systemic human B-cell depletion by a CD19xCD3 DART protein in humanized B...

The need to analyze trace narcotic samples rapidly for screening or confirmatory purposes is of increasing interest to the forensic, homeland security, and criminal justice sectors. This work presents a novel method for the detection and quantification of trace drugs and metabolites off of a swipe material using a thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS) co...

DASH is a library of distributed data structures and algorithms designed for running the applications on modern HPC architectures, composed of hierarchical network interconnections and stratified memory. DASH implements a PGAS (partitioned global address space) model in the form of C++ templates, built on top of DART – a run-time system with an abstracted tier above existing one-sided communica...

The current study applied gas chromatography-mass spectrometry (GC–MS), liquid (LC-MS), and thermal desorption direct analysis in real-time mass (TD-DART-MS) methods to the of black pepper (Piper nigrum L.) samples from different countries. powder were analyzed directly by TD-DART-MS without any extraction, but for GC–MS LC-MS methods, a methanol extraction procedure was employed before analysi...

Die Benutzerakzeptanz wird zunehmend als kritischer Faktor für die Entwicklung innovativer Anwendungen und deren Markterfolg angesehen. Der DART-Ansatz ist ein Modell zur Bewertung der Benutzerakzeptanz und kann als Steuerungsinstrument für die (wiederholte) Anpassung einer Anwendung an die Bedürfnisse der Anwender aufgefasst werden. Im Rahmen dieses Beitrages wird die Evaluierung der Benutzera...

INTRODUCTION Identifying patients with a high risk for drug-related problems (DRPs) might optimise the allocation of targeted pharmaceutical care during the hospital stay and on discharge. OBJECTIVE To develop a self-assessment screening tool to identify patients at risk for DRPs and validate the tool regarding feasibility, acceptability and the reliability of the patients' answers. DESIGN ...

Abstract In X-ray computed tomography, discrete tomography (DT) algorithms have been successful at reconstructing objects composed of only a few distinct materials. Many DT-based methods rely on divide-and-conquer procedure to reconstruct the volume in parts, which improves their run-time and reconstruction quality. However, this is based static rules, introduces redundant computation diminishe...

Previously a standard toxicological test termed as DarT (Danio rerio Teratogenic assay) using wild type zebrafish embryos has been established and it is widely applied in toxicological and chemical screenings. As an increasing number of fluorescent transgenic zebrafish lines with specific fluorescent protein expression specifically expressed in different organs and tissues, we envision that the...

A high throughput method for species identification and classification through chemometric processing of direct analysis in real time (DART) mass spectrometry-derived fingerprint signatures has been developed. The method entails introduction of samples to the open air space between the DART ion source and the mass spectrometer inlet, with the entire observed mass spectral fingerprint subjected ...