Volume 29, Number 3, May/June 1997 1980, the rate increased by 61% among adolescents, by 69% among women aged 20–24, by 67% among 25–29 year-olds and by 82% among women aged 30–34.2 Indeed, the rates for these latter groups have continued to rise since 1991, even as the birthrate among adolescents has stabilized and turned slightly downward. As a result of these trends, nonmarital births now ac...

1. Galilean Relativity and Newtonian Determinacy: 1/7/13 1 2. The Euler-Lagrange Equation: 1/9/13 3 3. Suddenly, Riemannian Geometry: 1/14/13 5 4. Examples of Natural Systems: 1/16/13 8 5. More on the Kepler Problem: 1/23/13 10 6. Rigid Bodies I: 1/28/13 12 7. Rigid Bodies II: 1/30/13 14 8. Rigid Bodies III: 2/4/13 15 9. The Legendre Transform and Projective Duality: 2/6/13 17 10. The Least Act...

ThehumanpregnaneX receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism–related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutationat threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in...

A four year-old-girl with Diamond-Blackfan anemia (DBA) that was resistant to corticosteroid treatment and transfusion dependent underwent (bone marrow transplantation) BMT from HLA identical sibling. The patient was conditioned with busulfan and cyclophosphamide and achieved complete marrow engraftment and mixed chimerism in DNA analysis. For the following 13 months she was not transfusion dep...