The title compounds contain the catena-arsenite [AsO(2)](n)(n-) unit, in which the As(III) atom is pyramidally coordinated to one terminal and two bridging O atoms, resulting in an infinite anionic chain. Ethylenediammonium catena-arsenite, (C(2)H(10)N(2))(0.5)[AsO(2)], is the first example of this anion in the company of an organic cation. The ethylenediammonium species interact with the [AsO(...

"Upper limits of normal" antistreptolysin O (ASO) and antideoxyribonuclease (ADN) B titers were determined on serum specimens from various age groups of pediatric patients with no history of a recent streptococcal infection and on healthy adult hospital employees. The upper limit of normal value is that level of antibody titer exceeded by no more than 15% of the total subjects in each age group...

This paper addresses a Permutation Flow-shop Scheduling Problem (PFSP) where there is a finite number of transporters between any two successive machines to carry jobs from one machine to the subsequent machine. In order to solve the problem, an effective Anarchic Society Optimization (ASO) algorithm is developed to find a sequence of jobs with nearly-minimum makespan. The proposed ASO algorith...

The structure of the title compound tris-odium aluminium bis-(arsenate), Na(3)Al(AsO(4))(2), is built up from AlO(4) and AsO(4) corner-sharing tetra-hedra, forming an undulating two-dimensional framework parallel to (100). The layers are constituted of large Al(6)As(6)O(36) rings made up from six AlO(4) and AsO(4) tetra-hedra in which two sodium cations are situated, the third sodium cation bei...

To identify a fast and sensitive method for screening for mutations in patients with imatinib- resistant chronic myeloid leukemia (CML), we compared allele specific oligonucleotide- polymerase chain reaction (ASO-PCR) assay with conventional direct sequencing. Among the 68 imatinib resistant CML patients studied, 18 amino acid substitutions were detected in 44 patients by two assays. The sensit...

The research described herein was a three-year exploratory descriptive study to examine how meaningful involvement (MIPA) is conceptualized and experienced in rural regions of the Maritime provinces of Canada. The focus of this paper is one aspect of the research; i.e., what motivates the clients of AIDS Service Organizations (ASOs) in rural Canada to become meaningfully involved? We interviewe...

Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using antisense oligonucleotides (ASOs) targeting CD40, would be beneficial in mouse models of glomerular injury and unilateral ureter obstruction. Admi...

We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemia. We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism in rats through a loss-of-function approach using a specific antisense oligonucleotide (ASO) to decrease...

PURPOSE Lipid nanoparticle (LNP) formulations facilitate tumor uptake and intracellular processing through an enhanced permeation and retention effect (EPR), and currently multiple products are undergoing clinical evaluation. Clusterin (CLU) is a cytoprotective chaperone induced by androgen receptor (AR) pathway inhibition to facilitate adaptive survival pathway signaling and treatment resistan...

An effective way to reduce LDL cholesterol, the primary risk factor of atherosclerotic cardiovascular disease, is to increase cholesterol excretion from the body. Our group and others have recently found that cholesterol excretion can be facilitated by both hepatobiliary and transintestinal pathways. However, the lipoprotein that moves cholesterol through the plasma to the small intestine for t...