Neurotensin (NT) exerts multiple functions in the central nervous system and peripheral tissues. Its actions are mainly mediated by a high-affinity G-protein-coupled receptor, the NT-1 receptor. In this study we demonstrated a nuclear NT binding site in different cellular models. We first noted that a large percentage of NT-1 receptor cell body immunoreactivity was located in the nuclear soma a...

Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3. Although NT has been reported to modulate GABAergic activity in the brain, the underlying cellular and molecular mechanisms of NT are elusive. Here, we examined the effects of NT on GABAergic transmission and the involved cellular and signaling mechanisms of NT in the hippocampus. Application of N...

OBJECTIVE To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis. MATERIALS AND METHODS We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 1...

Neurotrophin-3 (NT-3) promotes enteric neuronal development in vitro; nevertheless, an enteric nervous system (ENS) is present in mice lacking NT-3 or TrkC. We thus analyzed the physiological significance of NT-3 in ENS development. Subsets of neurons developing in vitro in response to NT-3 became NT-3 dependent; NT-3 withdrawal led to apoptosis, selectively in TrkC-expressing neurons. Antibodi...

DNA methylation is an important factor for the regulation of gene expression in early embryos. It is well known that the satellite I sequence is more heavily methylated in bovine somatic cell nuclear transfer (NT-SC) embryos than in embryos derived from in vitro fertilization (IVF). However, the methylation status of bovine embryos obtained by other procedures is not well known. To clarify DNA ...

This paper is intended to catalyze discussions on two intertwined systems topics. First, it presents early results from a latency study of Windows NT that identifies ome specific auses of long thread scheduling latencies, many of which delay the dispatching of runnable threads for tens of milliseconds. Reasons for these delays, including technical, methodological, and economic are presented and...

Imperialism in New Testament (related) films relates to an important aspect of the reception of the Bible in film. After a brief investigation of the concept imperialism, this contribution explores particular instances where imperialism and NT themes intersect in film: the relationship between imperialism, Jesus-followers and Romans; satirical approaches to imperialism in NT films; and, the int...

The word "mystery" as it occurs in ancient Greek and Semitic sources. as well as in the NT. refers to a secret which is only revealed to 'certain individuals. In the NT it is God who reveals the mystery and faithful believers who perceive it. Carnal believers and unbelievers are not able to understand the mystery. The mystery centers around the Lordship of Christ who is the Life of the church. ...