Newly synthesized allyloxymethyl purine and pyrimidine acyclonucleosides [Fig. 1, comp. 1-6] were tested in Syrian hamster, six days after heterotransplantations of Kirkman-Robbins hepatoma and compared with Th5, Th5P and PMT [Fig. 1, comp. 7-9]. 48 hours after intraperitoneal (i.p.) administration of AMT and Th5 in a dose of 80 mg per kg body weight, these compounds reduced tumor weight by 42%...

We have conducted a Phase 1 study of aminopterin (AMT) with leucovorin (LV) in 17 patients. AMT was administered by bolus injection every 7 to 14 days in dosages from 25 to 425 mg/sq m. LV rescue was instituted at 24 hr and continued for 48 to 72 hr. At dosages above 50 mg/sq m, we observed nephrotoxicity defined as greater than or equal to a 25% increase in serum creatinine 24 hr after AMT adm...

BACKGROUND Although amantadine (AMT) and rimantadine (RMT) are used to relieve or treat influenza A symptoms in healthy adults, little is known about the effectiveness and safety of these antivirals in preventing and treating influenza A in children and the elderly. OBJECTIVES The aim of this review was to systematically consider evidence on the effectiveness and safety of AMT and RMT in prev...

merican Medical Technologists (AMT) is somewhat unique among laboratory organizations in that it serves the dual roles of a certifying body and a professional membership association that provides its members an important benefit in the form of legislative monitoring and advocacy. AMT enjoys an excellent member-retention rate, especially in its MT and MLT membership categories — a testament that...

Advanced manufacturing technologies (AMTs) are perceived by companies to be an important element in surpassing competitiveness. However, excelling in today’s market is not as simple as the acquisition of new technologies alone. To achieve the desired benefits, the structure and infrastructure of organizations must match to ensure that the implementation of technologies lead to the expected bene...

AIM To evaluate the efficacy of amniotic membrane transplantation (AMT) for the management of conjunctival malignant melanoma and primary acquired melanosis (PAM) with atypia. METHODS Four consecutive patients with histologically proved invasive, primary conjunctival malignant melanoma were treated with wide surgical excision and AMT. Amniotic membrane grafts were harvested and processed unde...

Ammonium transport proteins of the Mep/Amt/Rh family include microbial and plant Mep/Amt members, crucial for ammonium scavenging, and animal Rhesus factors likely involved in ammonium disposal. Recent structural information on two bacterial Mep/Amt proteins has revealed the presence, in the hydrophobic conducting pore, of a pair of preserved histidines proposed to play an important role in sub...

Combining evolutionary models with behavioral experiments can generate powerful insights into the evolution of human behavior. The emergence of online labor markets such as Amazon Mechanical Turk (AMT) allows theorists to conduct behavioral experiments very quickly and cheaply. The process occurs entirely over the computer, and the experience is quite similar to performing a set of computer sim...

Brain cortices or bulk-isolated neuronal cell bodies prepared from cortices of 8-day old male rats were used as the source of a I-methyl adenine-specific tRNA methyltransferase (tRNA-AMT). Ammonium sulfate fractionation and chromatography on spheroidal hydroxylapatite and Sephadex (3-200 yielded an 80-fold purified enzyme, as determined by using E. coli bulk tRNA as substrate. The kinetic param...

The Auditory Modeling Toolbox (AMT) is a MATLAB/Octave toolbox for the development and application of computational auditory models with particular focus on binaural hearing. AMT aims consistent implementation models, well-structured in-code documentation, inclusion data required to run models. motivation provide able reproduce model predictions allowing students researchers work advance existi...