نتایج جستجو برای: سیکلین d1
تعداد نتایج: 19316 فیلتر نتایج به سال:
Following acute hepatic injury, the metabolic capacity of the liver is altered during the process of compensatory hepatocyte proliferation by undefined mechanisms. In this study, we examined the regulation of de novo lipogenesis by cyclin D1, a key mediator of hepatocyte cell cycle progression. In primary hepatocytes, cyclin D1 significantly impaired lipogenesis in response to glucose stimulati...
Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines. Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 expression. Transcription rates of the cyclin D1 gene, studied using a cyclin D1 promoter-lucifera...
Although specialized pro-resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive. Here, we show that TLR7, a receptor recognizing viral ssRNA and damaged self-RNA, mobilizes the docosahexaenoic acid (DHA)-derived biosynthetic pathways that lead to the ...
Introduction: Dopamine plays an important role in the central nervous system for modulating food intake. Dopamine receptors are distributed within the hypothalamus, and expression of D1 receptors is significant in hypothalamic paraventricular nucleus (PVN). Therefore, the aim of this study was to find if PVN-microinjected SKF38393, D1 receptor agonist, may modulate food intake. Methods: Gui...
The present study conducted an immunohistochemical investigation of cyclin D1 and Ki-67 expression in oral squamous cell carcinoma (SCC) to evaluate the correlations between cell differentiation, cell proliferation and metastasis, and the effect of anticancer drug medication and cyclin D1 expression. Cyclin D1 and Ki-67 were detected clearly in the nuclei of 35 SCC samples. No correlation betwe...
We define the contact homology algebra for any manifold and show that it is an invariant of manifold. More precisely, given a (M,?) some auxiliary data D, we HC(D). If D1 D2 are two choices (M,?), then HC(D1) HC(D2) isomorphic. use simplified version Kuranishi perturbation theory, consisting semi-global charts.
The cyclin D1 gene encodes a regulatory subunit of the holoenzyme that phosphorylates and inactivates the pRb tumor suppressor to promote nuclear DNA synthesis. cyclin D1 is overexpressed in human breast cancers and is sufficient for the development of murine mammary tumors. Herein, cyclin D1 is shown to perform a novel function, inhibiting mitochondrial function and size. Mitochondrial activit...
تاثیر تراکم بوته (25، 35 و 45 بوته در مترمربع بهترتیب D3, D2, D1) و تلقیح با باکتری رایزوبیوم (بدون تلقیح، تلقیح با رایزوبیوم، تلقیح با رایزوبیوم به همراه عناصر میکرو بهترتیبR2, R1, R0) بر رشد و عملکرد نخود، در سال 1387 در مزرعه تحقیقاتی کشاورزی دانشگاه محقق اردبیلی بهصورت فاکتوریل در قالب طرح بلوک¬های کامل تصادفی در 4 تکرار بررسی گردید. تراکم بوته بر تعداد دانه در نیام و وزن 100 دانه اثر غی...
This paper introduces the technique of fault distance estimation based on modal transformation and signal processing. The recorded faulted phase currents are applied to Karrenbauer model these component decomposed into detail coefficients by use Daubechies wavelet, db6. recorder installed at terminal feeder records different time delays between components. In order find distance, delay values c...
High-molecular weight (HMW (glutenin subunits are encoded by the Glu-1 loci (Glu-A1, Glu-B1 and <sp...
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