Initiation of translation involves the assembly of a ribosome complex with initiator tRNA bound to the peptidyl site and paired to the start codon of the mRNA. In bacteria, this process is kinetically controlled by three initiation factors--IF1, IF2, and IF3. Here, we show that deletion of helix H69 (∆H69) of 23S rRNA allows rapid 50S docking without concomitant IF3 release and virtually elimin...

Cisplatin is widely used for the treatment of solid tumors, including small cell lung cancers, but its success is often compromised due to relapse and resistance to further treatment. p70 ribosomal S6 kinase (p70S6K) has been shown to be upregulated in lung cancer cells. In the present study, we investigated whether the p70S6K pathway contributes to cisplatin resistance in human small cell lung...

We construct an endogenous growth model and we employ empirical analysis to investigate the link between foreign aid and production inefficiency in the presence of different political orientations in the recipient country. Using a panel of 124 countries from 1971 to 2007 and the production frontier toolbox, controlling for unobserved heterogeneity, time horizons, the sources of aid, and the tim...

Abstract. Since 2021, Russia has maintained a list of unfriendly countries. This and the import ban introduced in 2014 are some main economic sanctions uses to influence trading partners. paper attempts quantify effect putting partner on countries compared Russian ban. The study data trade flows between its partners from UN COMTRADE database for select agri-food products. Employing gravity fram...

Achieving the 2030 sustainable development goals (SDGs) in Nigeria requires and inclusive economic growth. There is no consensus among economists on effect of monetary policy The results previous studies growth are mixed. main objective this paper to evaluate order ascertain if can be used achieve SDGs Nigeria. from 1991 2020 was evaluated using ordinary least squares regression model. findings...

À partir des données issues du recensement général de la population 2014, nous analysons à l’échelle bassins vie, le lien entre migration résidentielle destination espaces ruraux et périurbains ségrégation socio-spatiale. Nos résultats montrent que les individus sont sensibles aux caractéristiques sociodémographiques voisina...

We consider testing about the slope parameter β when Y −Xβ is assumed to be an exchangeable process conditionally on X. This framework encompasses the semi-parametric linear regression model. We show that the usual Fisher’s procedure have non trivial exact rejection bound under the null hypothesis Rβ = γ. This bound derives from the Markov inequality and a close inspection of multivariate momen...