This paper proposes a way to combine the Mesh Adaptive Direct Search (MADS) algorithm, which extends the Generalized Pattern Search (GPS) algorithm, with the Variable Neighborhood Search (VNS) metaheuristic, for nonsmooth constrained optimization. The resulting algorithm retains the convergence properties of MADS, and allows the far reaching exploration features of VNS to move away from local s...

Abstract We discuss the prospects for identifying nearest isolated black holes (IBHs) in our Galaxy. IBHs accreting gas from interstellar medium likely form magnetically arrested disks (MADs). show that thermal electrons MADs emit optical signals through synchrotron process while nonthermal accelerated via magnetic reconnections a flat-spectrum radiation X-ray to MeV gamma-ray ranges. The Gaia ...

The Arabidopsis MADS domain proteins API, AP3, PI, andAG specify floral organ identity. All of these proteins contain a MADS domain required for DNA binding and dimerization; a region termed L (linker between MADS domain and K domain), which plays an important role in dimerization specificity; the K domain, named for its similarity to the coiled-coil domain of keratin; and a C-terminal region o...

This work introduces the use of the treed Gaussian process (TGP) as a surrogate model within the mesh adaptive direct search (MADS) framework for constrained blackbox optimization. It extends the surrogate management framework (SMF) to nonsmooth optimization under general constraints. MADS uses TGP in two ways: one, as a surrogate for blackbox evaluations; and two, to evaluate statistical crite...

We isolated and characterized two ovule-specific MADS box cDNAs from petunia, designated floral binding protein (fbp) genes 7 and 11. The putative protein products of these genes have approximately 90% of their overall amino acid sequence in common. In situ RNA hybridization experiments revealed that both genes are expressed in the center of the developing gynoecium before ovule primordia are v...

We isolated and characterized two ovule-specific MADS box cDNAs from petunia, designated floral binding protein (fbp) genes 7 and 11. The putative protein products of these genes have -90% of their overall amino acid sequence in common. In situ RNA hybridization experiments revealed that both genes are expressed in the center of the developing gynoecium before ovule primordia are visible. At la...

MADS-domain proteins are important transcription factors involved in many biological processes of plants. In our study, a tomato MADS-box gene, SlFYFL, was isolated. SlFYFL is expressed in all tissues of tomato and significantly higher in mature leave, fruit of different stages, AZ (abscission zone) and sepal. Delayed leaf senescence and fruit ripening, increased storability and longer sepals w...

Our work is developed in the context of spatiotemporal data modeling and more particularly of urban data modeling. Our goal is to propose a methodology describing the overall process of urban data modeling from the design phase to the implementation in an information system. For that, we propose, within a GIS, an approach based on a conceptual model specific to spatiotemporal data modeling MADS...

Blackbox optimization deals with situations in which the objective function and constraints are typically computed by launching a time-consuming computer simulation. The subject of this work is the Mesh Adaptive Direct Search (MADS) class of algorithms for blackbox optimization. We propose a way to dynamically scale the mesh, which is the discrete spatial structure on which MADS relies, so that...

The MADS domain homeotic proteins APETALA1 (AP1), APETALA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) combinatorially specify the identity of Arabidopsis floral organs. AP1/AP1, AG/AG, and AP3/PI dimers bind to similar CArG box sequences; thus, differences in DNA-binding specificity among these proteins do not seem to be the origin of their distinct organ identity properties. To assess the overal...