The expressions of hypoxia-inducible genes are upregulated by hypoxia-inducible factor 1 (HIF-1), which is a heterodimer of HIF-1alpha and HIF-1beta/ARNT (aryl hydrocarbon receptor nuclear transporter). Under hypoxic conditions, HIF-1alpha becomes stabilized and both HIF-1alpha and ARNT are translocated into the nucleus and codimerized, binding to the HIF-1 consensus sequence and transactivatin...

Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although the α subunit of hypoxia-inducible factor (HIF)-1 is not degraded with bortezomib treatment, the...

هدف: با توجه به نگرانی‌های اجتماعی موجود در سال‌های اخیر دلیل بحران‌های اقتصادی، اجتماعی، مالی و زیست‌محیطی ناشی از تحریم‌ها، خط‌مشی دولت‌ها برای افزایش تاب‌آوری سمت اقتصاد مقاومتی سوق پیدا کرده است. هدف این پژوهش طراحی تبیین مدل سیاست‌گذاری دولت الکترونیک رویکرد وزارت علوم است.طراحی/ روش‌شناسی/ رویکرد: تحقیق حاضر لحاظ کاربردی توسعه‌ای بوده تکنیک تحلیل تم حاصل مصاحبه مدیران عالی اساتید دانشگاه ...

During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of hif-1 loss-of-fu...

Hypoxia-inducible factor (HIF) transcription factors implement essential changes in gene expression that enable animals to adapt to low oxygen (hypoxia). The stability of the C. elegans HIF-1 protein is controlled by the evolutionarily conserved EGL-9/VHL-1 pathway for oxygen-dependent degradation. Here, we describe vhl-1-independent pathways that attenuate HIF-1 transcriptional activity in C. ...

PURPOSE Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates VEGF expression through the activation of the transcriptional factor, hypoxia-inducible factor 1 (HIF-1). We tested the hypothesis that an effect of androgens on VEGF expression is regulated direct...

Background: It is expected that the expression of key enzymes glycolysis pathway, specially PFK-1, increases tumor cells and so enhances function this pathway. The p53 HIF-1 proteins are regulators PFK-1 LDH enzymes. This study was performed to investigate changes in LDH-A, p53, HIF-1α genes identify metabolic non-small cell lung carcinoma (NSCLC) samples. Methods: A number 30 tumors their adja...