نتایج جستجو برای: فرایند تحلیل شبکهای anp

تعداد نتایج: 262643  

Journal: :Cardiovascular research 1999
R Willenbrock M Scheuermann G Thibault M Haass K Höhnel J Bohlender F C Luft R Dietz

OBJECTIVE In heart failure atrial natriuretic peptide (ANP) release in response to volume expansion is impaired while the renin-angiotensin system is activated. This study was designed to test the hypothesis that ANP release in heart failure is dependent on an activated angiotensin system. METHODS We studied the ANP and renin-angiotensin systems in a rat model of shunt-induced high-output hea...

2011
Lia Millucci Eugenio Paccagnini Lorenzo Ghezzi Giulia Bernardini Daniela Braconi Marcella Laschi Marco Consumi Adriano Spreafico Piero Tanganelli Pietro Lupetti Agnese Magnani Annalisa Santucci

AIMS Atrial Natriuretic Peptide (ANP)-containing amyloid is frequently found in the elderly heart. No data exist regarding ANP aggregation process and its link to pathologies. Our aims were: i) to experimentally prove the presumptive association of Congestive Heart Failure (CHF) and Isolated Atrial Amyloidosis (IAA); ii) to characterize ANP aggregation, thereby elucidating IAA implication in th...

2005
Ariela Benigni Norberto Perico Jacek Dadan Maurizio Gabanelli Miriam Galbusera Paola Boccardo Tiziana Mennini Giuseppe Remuzzi

Glomerular hyperfiltration in streptozotocin-induced diabetes mellitus in rats may be mediated by atrial natriuretic peptide (ANP). We wanted to evaluate plasma levels of ANP and plasma volume in relation to renal ANP receptor density and affinity in rats 6 weeks after induction of diabetes. Plasma levels of immunoreactive ANP were significantly higher in hyperglycemic diabetic (75.2+8.3 pg/ml)...

2017
Katie Aleck Kelly Hallman Meghan Quigley Victoria Lloyd Monica Szmyd Dana Ruskin Tyler Bedgood Sumi Dinda

The atrial natriuretic peptide (ANP) hormone is secreted by cardiac atrial myocytes and acts to regulate blood pressure homeostasis in humans. Previous research indicates ANP treatment significantly decreases the proliferation of human prostate cancer cells, pancreatic adenocarcinoma, and breast cancer cells. Minimal studies have been conducted with regard to ANP regulating tumor suppressor gen...

Journal: :Circulation research 1992
D J Meyer V H Huxley

Microvascular functions have been shown to be sensitive to agents associated with changes in cyclic nucleotide levels. The central hypothesis of the current study was that one measure of capillary exchange capacity, hydraulic conductivity (Lp), would be elevated by agents shown to elevate cellular levels of cGMP. To evaluate the hypothesis, frog mesenteric capillary Lp was measured during lumin...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2002
Xun Cui Jin Fu Wen Jing Yu Jin Wen Xie Xu Sung Zoo Kim Suhn Hee Kim Ho Sub Lee Kyung Woo Cho

Regulation of atrial release of atrial natriuretic peptide (ANP) is coupled to changes in atrial dynamics. However, the mechanism by which mechanical stretch controls myocytic ANP release must be defined. The purpose of this study was to define the mechanism by which cAMP controls myocytic ANP release in perfused, beating rabbit atria. The cAMP-elevating agents forskolin and 3-isobutyl-1-methyl...

Journal: :Biological research 1998
M P Boric J A Bravo M Corbalan C Vergara J S Roblero

In anesthetized rats, the renal excretory actions of atrial natriuretic peptide (ANP) are inhibited by intravenous or intraperitoneal injections of bradykinin. To elucidate the mechanisms underlying this inhibition, we evaluated bradykinin effects on: i- ANP-induced natriuresis and diuresis in isolated perfused rat kidneys, and ii- ANP-induced cGMP production in rat renal medulla in vitro. In p...

Journal: :Circulation 1990
Y Hirooka A Takeshita T Imaizumi S Suzuki M Yoshida S Ando M Nakamura

It has been shown that renal responses to atrial natriuretic peptide (ANP) are markedly attenuated in patients with heart failure. This study aimed to determine if vasodilative response to ANP is altered in patients with heart failure. In patients with heart failure (n = 7) and age-matched normal subjects (n = 7), forearm blood flow was measured using a strain-gauge plethysmograph during intra-...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
D Richard C W Bourque

Atrial natriuretic peptide (ANP) and its receptors are present in hypothalamic nuclei containing the magnocellular neurosecretory cells (MNCs), which release vasopressin and oxytocin. In the rat, intracerebroventricular injections of ANP inhibit the release of both hormones in response to hypertonicity. Although these findings suggest a role for endogenous ANP in the central control of fluid ba...

Journal: :The Journal of clinical investigation 1986
B J Ballermann K D Bloch J G Seidman B M Brenner

The mechanisms that mediate renal "escape" from the sodium-retaining effects of mineralocorticoids are incompletely understood. This study was undertaken to determine whether atrial natriuretic peptide (ANP) may play a role in the escape phenomenon. Immunoreactive ANP in rat plasma increased 2.5-fold above baseline values at 12 and 24 h after a single depot injection of desoxycorticosterone ace...

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