نتایج جستجو برای: فعال کنندهی پلاسمینوژن بافتی pa t
تعداد نتایج: 766623 فیلتر نتایج به سال:
Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro models of the bloodbrain barrier. t-PA caused a concentrationdependent increase in permeability. This effect was dependent on plasmin formation and potentiated in the presence of plasminogen. An inactive t-PA varian...
Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro models of the blood-brain barrier. t-PA caused a concentration-dependent increase in permeability. This effect was dependent on plasmin formation and potentiated in the presence of plasminogen. An inactive t-PA vari...
Given a set of positive integers A = {a1, . . . , an}, we study the number pA(t) of nonnegative integer solutions (m1, . . . ,mn) to ∑n j=1mjaj = t. We derive an explicit formula for the polynomial part of pA. Let A = {a1, . . . , an} be a set of positive integers with gcd(a1, . . . , an) = 1. The classical Frobenius problem asks for the largest integer t (the Frobenius number) such that m1a1 +...
چکیده: هدف از این پژوهش مقایسه تأثیر انواع انقباض ایزوکینتیک بر سیستم فیبرینولیتیک بود. بدین منظور، 10 مرد سالم با سابقه فعالیت تفریحی (میانگین ± انحراف معیار؛ سن، 4/3±1/26 سال؛ قد، 5/5±5/177 سانتی متر و وزن 8/12±5/76 کیلوگرم) داوطلبانه در چهار جلسه جداگانه به فاصله یک هفته در این پژوهش شرکت نمودند. در جلسه اول قد، وزن، bmi، درصدچربی و گشتاور اندازه گیری شد. در جلسات دوم، سوم و چهارم تمامی آزم...
White matter (WM) lesions in preterm newborns may lead to cerebral palsy. To study WM lesions in a mouse model, we used intrapallial stereotactic injections of ibotenic acid, an N-methyl-D-aspartate receptor agonist. Previous studies support a contribution of tissue-type plasminogen activator (t-PA) to the brain lesions seen in various adult excitotoxic models. Therefore, we studied both 5-day-...
The secretion of tissue-type plasminogen activator (t-PA) from melanoma cells (Bowes) was investigated with or without monensin treatment. Monensin inhibited secretion of t-PA from the cells to the medium in a dose-and time-dependent manner. The inhibition was accompanied by an intracellular accumulation of t-PA. Electrophoretic enzymography of the cell homogenate showed the main lytic zone at ...
This study is undertaken to design zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator (t-PA) for thrombolytic therapy where the t-PA activity can be recovered in the blood circulation upon ultrasound irradiation. Various molecular weights of gelatin were complexed with t-PA by their simply mixing in aqueous solution. Then, zinc acetate, calcium acetate or magnesium acet...
We evaluated the effect of r-hirudin and/or tissue-plasminogen activator (t-PA) in a model of DIC in rabbits induced by i.v. infusion of 100 micrograms/kg/h/6 h endotoxin. Rabbits were treated with saline (endotoxin control group), r-hirudin at 0.3 mg/kg/h/6 h, t-PA at 0.3 mg/kg for 90 min and r-hirudin plus t-PA at the doses described above. The best results were achieved when r-hirudin and t-...
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