The tensile strength (TS) of rocks is an important parameter in the design of a variety of engineering structures such as the surface and underground mines, dam foundations, types of tunnels and excavations, and oil wells. In addition, the physical properties of a rock are intrinsic characteristics, which influence its mechanical behavior at a fundamental level. In this paper, a new approach co...

purpose: to report multiple astrocytic hamartomas in a patient with tuberous sclerosis (ts). patient and findings: a 16-year-old girl with ts without any ocular complaint was referred for ophthalmologic examination. she had papular rash on her face and other skin lesions elsewhere in the body which were specific for ts. multiple well-circumscribed elevated lesions characteristic of astrocytic h...

Four bacterial strains, Pseudomonas chlororaphis (PA-23), Bacillus amyloliquefaciens (BS6), Pseudomonas sp. (DF41) and B. amyloliquefaciens (E16) which had been found to have biocontrol activity in vitro assays against Sclerotinia sclerotiorum, the causal agent of stem rot of canola, were tested for their efficacy in greenhouse and field conditions. Microscopic studies showed that P. chlororaph...

We estimate “CEO style” wage equations using two longitudinal matched employeremployee data sets. We develop a model in which the wages of all employees in a ...rm are linked to those of top management, which generates speci...c empirical implications that have already been tested on CEOs. We provide evidence that the wages of “regular” employees in large ...rms are linked to accounting and sto...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Epidemiologic studies support the premise that Allium vegetables may lower the risk of cancers. The beneficial effects appear related to the organosulfur products generated upon processing of Allium. Leukemia cells from patients with acute myeloid leukemia (AML) display high proliferative capacity and have a reduced capacity of undergoing apoptosis and maturation. Whether the sulfur-containing ...

RNA interference is a post-transcriptional mechanism by which double-stranded RNA specifically silence expression of a corresponding gene. Small interfering double-stranded RNA (siRNA) of 21-23 nucleotides can induce the process of RNA interference. Studies from our laboratory have shown that translation of thymidylate synthase (TS) mRNA is controlled by its own protein end-product TS in a nega...