نتایج جستجو برای: لنفوسیتهای نفوذ یافته درون تومور til
تعداد نتایج: 188593 فیلتر نتایج به سال:
Purpose Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic melanoma can be highly effective, but attrition due to progression before TIL administration (32% in prior institutional experience) remains a limitation. We hypothesized that combining ACT with cytotoxic T lymphocyte-associated antigen 4 blockade would decrease attrition and allow more patients to rec...
position paper. Historically two types of NLP have been investigated: fully automated processing of language by machines (NLP) and autonomous processing of natural language by people, i.e. the human brain (psycholinguistics). We believe that there is room and need for another kind, INLP: interactive natural language processing. This intermediate approach starts from peoples’ needs, trying to br...
Transparent Intensional Logic (TIL) is a highly expressive logical system apt for the logical analysis of natural language. It operates with a single procedural semantics for all kinds of logical-semantic context, whether extensional, intensional or hyper-intensional, while adhering to the compositionality principle throughout. The reason why we vote for a rich procedural semantics is this. A c...
UNLABELLED Patients with leptomeningeal disease (LMD) from melanoma have very poor outcomes and few treatment options. We present a case of intrathecal (i.t.) administration of autologous tumor-infiltrating lymphocytes (TIL) in a patient with LMD from metastatic melanoma. The patient developed LMD after previous treatments with surgery, high-dose bolus interleukin-2 (HD IL2), and systemic TIL i...
Thirteen patients with epithelial ovarian cancer, who did not show any detectable lesion after cisplatin-containing chemotherapy following primary operation, were treated with adoptive transfer of tumor-infiltrating lymphocytes (TIL group). Eleven patients with almost equivalent conditions of disease, who were treated with only chemotherapy following primary operation, served as a control group...
BACKGROUND Nasopharyngeal carcinoma (NPC) has a high propensity for metastasis. The purpose of this study was for us to determine whether serglycin expression can be used to predict distant metastases. METHODS Serglycin expression of tumor tissue of 112 patients with NPC was assessed based on percentage of tumor cells expressing serglycin, staining intensity, percentage of tumor-infiltrated l...
We readwith great interest the comprehensive and timely review article by Sznol and Chen (1) in the March 1, 2013 issue of Clinical Cancer Research. This review summarized the PD-1 costimulatory (coinhibitory) signaling pathway in activated T cells mediated by PD-L1 or PD-L2 binding and its implications for antitumor therapy. However, the authors did not comment on the strategy of combining PD-...
The objective of this study was to determine whether tumor-infiltrating B cells (TIL-B) of infiltrating ductal carcinoma (IDC) of the breast represent a tumor-specific humoral immune response. Immunohistochemical analysis of three Her-2/neu-negative IDC tumors from geriatric patients showed that TIL-B cluster in structures similar to germinal centers containing CD20(+) B lymphocyte and CD3(+) T...
PURPOSE Cancer immunotherapy with adoptive transfer of tumor-infiltrating lymphocytes (TIL) represents an effective treatment for patients with metastatic melanoma, with the objective regressions in up to 72% of patients in three clinical trials. However, the antigen targets recognized by these effective TILs remain largely unclear. EXPERIMENTAL DESIGN Melanoma patients 2359 and 2591 both exp...
PURPOSE Psychosocial stress has been related to impaired immunity in cancer patients. However, the extent to which these relationships exist in immune cells in the tumor microenvironment in humans has not been explored. We examined relationships among distress, social support, and natural killer (NK) cell activity in ovarian cancer patients in peripheral-blood mononuclear cells (PBMC), ascitic ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید