A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa. Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR. However, the successful application of small peptides in a theranostic approach is often hampered by th...

The Escherichia coli lactose carrier is an energy-transducing H+/galactoside cotransport protein which strictly couples sugar and proton transport in 1:1 stoichiometry. Here we describe five lactose carrier mutants which catalyze "uncoupled" sugar-independent H+ transport. Symptoms similar to uncoupling by a proton ionophore have been observed in cells expressing these mutant carriers. The muta...

Amaç: Son yıllarda, hedefe yönelik radyonüklid tedavisindeki ilerlemeler sayesinde hastalıkların erken teşhis ve tedavisinde önemli gelişmeler kaydedilmiştir. Tanı tedavi yöntemlerini birleştiren “teranostik” kavramının doğmasıyla Lutesyum-177 (Lu-177), tedavide bir yer edinmiş bu alanda öncü bileşik haline gelmiştir. Bu derlemede, radyofarmasötikler, tedavi, teranostikler Lu-177 ile ilgili tem...

156 Jakaša, T., Osmanagić Bedenik, N., Iliopoulos, F., Određivanje učinkovitosti sustava..., Energija, god. 57(2008), br. 2., str. 156-177 Jakaša, T., Osmanagić Bedenik, N., Iliopoulos, F., Determination of the Effectiveness of Risk..., Energija, vol. 57(2008), No. 2, pp. 156-177 SUSTAVI UPRAVLJANJA RIZICIMA U PODUZEĆIMA ELEKTROPRIVREDE DETERMINATION OF THE EFFECTIVENESS OF RISK MANAGEMENT SYST...

This research studies the impact of information technology enabled coordination on product modularization in the automotive industry. A structural equation model is tested based on 177 responses to questionnaires from 177 Korean first tier automotive suppliers. The results provide support for the hypothesis that high quality of exchanged information enables better supply chain coordination, whi...

Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.

BACKGROUND Little is known about the molecular epidemiology of hepatitis C virus (HCV) infection in Central China. METHODOLOGY/PRINCIPAL FINDINGS A total of 570 patients from Hubei Province in central China were enrolled. These patients were tested positive for HCV antibody prior to blood transfusion. Among them, 177 were characterized by partial NS5B and/or Core-E1 sequences and classified i...

The aim of this study was to determine whether shorter-lived radionuclides can reduce red marrow (RM) toxicity for i.p. radioimmunotherapy (RIT). The potential radionuclides, which included Lu-177, I-131, Y-90, Re-186, Re-188, and Ho-166, were attached to antibody CC49. Each radiopharmaceutical was assumed to have identical in vivo pharmacokinetics. Blood and whole body retention data acquired ...

The aim of this study was to determine whether shorter-lived radionuclides can reduce red marrow (RM) toxicity for i.p. radioimmunotherapy (RIT). The potential radionuclides, which included Lu-177, 1-131, Y-90, Re-186, Re-188, and Ho-166, were attached to antibody CC49. Each radiopharmaceutical was assumed to have identical in vivo pharmacokinetics. Blood and whole body retention data acquired ...