OBJECTIVES To assess the efficacy of a cannabis-based medicine (CBM) in the treatment of pain due to rheumatoid arthritis (RA). METHODS We compared a CBM (Sativex) with placebo in a randomized, double-blind, parallel group study in 58 patients over 5 weeks of treatment. The CBM was administered by oromucosal spray in the evening and assessments were made the following morning. Efficacy outcom...

By utilizing condition monitoring information collected from wind turbine components, condition based maintenance (CBM) strategy can be used to reduce the operation and maintenance costs of wind power generation systems. The existing CBM methods for wind power generation systems deal with wind turbine components separately, that is, maintenance decisions are made on individual components, rathe...

BACKGROUND Cognitive bias modification (CBM), a set of techniques for modifying bias in information processing-is considered a novel intervention for social anxiety disorder (SAD), which has drawn considerable interest from researchers. However, the effects of CBM on SAD are not consistent. Some studies have demonstrated significant positive effects compared to control groups, while others have...

The field of coalbed methane (CBM) is well recognized as being able to provide clean fuels and reduce carbon dioxide emissions, thereby helping to reduce global warming. It is an effective solution to the problem of global climate change. Given the importance of CBM research on sustainable development, we have developed a comprehensive and powerful visualization of Chinese CBM research to help ...

In this paper we introduce a new logical calculus of the Region Connection Calculus (RCC) family, RCC*-9. Based on nine topological relations, RCC*-9 is an extension of RCC-8 and models topological relations between multi-type geometric features: therefore, it is a calculus that goes beyond the modeling of regions as in RCC-8, being able to deal with lower dimensional features embedded in a giv...

Tatsuhiko Sato, Koji Niita, Norihiro Matsuda, Shintaro Hashimoto, Yosuke Iwamoto, Shusaku Noda, Hiroshi Iwase, Hiroshi Nakashima, Tokio Fukahori, Satoshi Chiba and Lembit Sihver Japan Atomic Energy Agency, Shirakata-Shirane 2-4, Tokai, Ibaraki, 319-1195, Japan; Research Organization for Information Science and Technology, Shirakata-Shirane 2-4, Tokai, Ibaraki, 319-1106, Japan; High Energy Accel...

We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45+ tumour-infiltrating cells (TIL) in mice carrying syngeneic TC-1 and TC-1/A9 HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative. The chemotherapy resulted in the decrease of the CD4+ and CD8+ TIL, increase of the Gr-1+/CD11b+ TIL, no changes in the...

BACKGROUND Cognitive bias modification (CBM) interventions are strongly advocated in research and clinical practice. AIMS To examine the efficiency of CBM for clinically relevant outcomes, along with study quality, publication bias and potential moderators. METHOD We included randomised controlled trials (RCTs) of CBM interventions that reported clinically relevant outcomes assessed with st...

Recent trends reveal that models of culture aid in mapping the design and analysis of information and communication technologies. Therefore, models of culture are powerful tools to guide the building of instructional products and services. This research examines the construction of the culture based model (CBM), a model of culture that evolved from historical and linguistic analyses of instruct...