BACKGROUND HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa. METHODS In this open, non-inferiority trial in three centr...

This study aims to optimize the void function by engineering material handling so that in post-mining stage it is expected Void Northern area of 40 Ha with drainage RL 20 and Southern 140 11 be used as a source irrigation for rice fields become location planned infrastructure development Solar Power Plants. Descriptive quantitative data analysis assisted using Geovia Minex, X Pac, Autocad Land ...

Let S = {x1,x2, . . . ,xn} be a set of positive integers, and let f be an arithmetical function. The matrices (S) f = [ f (gcd(xi,xj))] and [S] f = [ f (lcm[xi,xj])] are referred to as the greatest common divisor (GCD) and the least common multiple (LCM) matrices on S with respect to f , respectively. In this paper, we assume that the elements of the matrices (S) f and [S] f are integers and st...

Laser Capture Microdissection (LCM) is an innovative technique which permits the rapid and reliable procurement of pure cell populations from heterogeneous tissue sections. After LCM, RNA isolated from pure cell populations was amplified to generate adequate amounts of antisense RNA (aRNA) for hybridization, and the differential gene expression profiles were analyzed between two experimental gr...

BACKGROUND Heart failure patients with reduced ejection fraction (HFREF) are heterogenous, and our ability to identify patients likely to respond to therapy is limited. We present a method of identifying disease subtypes using high-dimensional clinical phenotyping and latent class analysis that may be useful in personalizing prognosis and treatment in HFREF. METHODS A total of 1121 patients w...

BACKGROUND Brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) have been recently marketed as adjunctive treatments for focal onset seizures. To date, no randomized controlled trial (RCT) has directly compared BRV with ESL, LCM, or PER. PURPOSE To compare BRV with the other add-on AEDs in patients with uncontrolled focal epilepsy, estimating their efficac...

Long-term cognitive disability after TBI is associated with injury-induced neurodegeneration in the hippocampus-a region in the medial temporal lobe that is critical for learning, memory and executive function. Hence our studies focus on gene expression analysis of specific neuronal populations in distinct subregions of the hippocampus. The technique of laser capture microdissection (LCM), intr...

During persistent infection of mice with the lymphocytic choriomeningitis (LCM) virus approximately 3% of leukocytes were found to contain viral antigen and to produce infectious virus. Morphologically, infected cells were shown not to be lymphoblasts and their numbers were not reduced by removal of mononuclear phagocytes. We conclude that in LCM virus carrier mice true lymphocytes participate ...