BACKGROUND APV102002 was an open-label study comparing a dual-boosted HIV-1 protease inhibitor (PI) [fosamprenavir/lopinavir/ritonavir (FPV/LPV/RTV; 1400 mg/533 mg/133 mg twice daily)] and a high dose of FPV/RTV 1400 mg/100 mg twice daily (HD-FPV/RTV) versus the standard FPV/RTV 700 mg/100 mg twice-daily (STD-FPV/RTV) regimen for 24 weeks. METHODS Adult patients with prior failure to two or m...

LPVTools is a MATLAB toolbox that is being developed to perform gain-scheduled Linear Parameter-Varying (LPV) control of aeroservoelastic systems. This paper outlines the LPV modeling, analysis and controller synthesis features of this toolbox. The features of the toolbox are illustrated by an application example, where a grid-based LPV model is developed for the X-56A aircraft using LPVTools. ...

In this paper we consider the problem of analyzing the stability of a discrete time nonlinear system in quasi-LPV form under an optimization based controller subject to constraints. We show that by representing the control law, which is computed on-line as the solution to a constrained optimization problem, by the Kuhn-Tucker conditions, stability questions can be reformulated as implications. ...

This paper deals with the practical applicability of the control design methods that are based on the descriptor representation for robotic manipulators. The nonlinear model of a manipulator can be reformulated as a linear parameter varying (LPV) model with rational parametric dependence. The statespace LPV model can then be converted into a LPV descriptor model with affine parametric dependenc...

We assessed pharmacokinetic (PK) parameters of reduced dose lopinavir/ritonavir (LPV/r) and compared generic and branded tablets. Twenty HIV-infected patients using protease inhibitors with HIV RNA ,50 copies per milliliter were randomized to generic or branded LPV/r 200/50mg twice daily (BID). At week 2, PK-sampling was performed. Patients crossed over to the other arm until week 12, with anot...

The paper presents a novel model order reduction technique for large-scale linear parameter varying (LPV) systems. The approach is based on decoupling the original dynamics into smaller dimensional LPV subsystems that can be independently reduced by parameter varying reduction methods. The decomposition starts with the construction of a modal transformation that separates the modal subsystems. ...

Several genotypic interpretation scores have been proposed for the evaluation of susceptibility to lopinavir/ritonavir (LPV/r) but have not been compared using an independent data set. This study was a retrospective multicenter cohort of patients initiating LPV/r-based therapy. The virologic response (VR) was defined as a viral load of <500 copies/ml at week 24. The genotypic interpretation sco...

In this paper an analysis of the complexity involved in the implementation and synthesis of linear parameter-varying (LPV) controllers is presented. Its purpose is to provide guidance in the selection of a synthesis approach for practical LPV control problems and reveal directions for further research with respect to complexity issues in LPV control. Standard methods are classified into polytop...

Mathematical models of physical systems are pervasive in engineering. These models can be used to analyze properties of the system, to simulate the system, or synthesize controllers. However, many of these models are too complex or too large for standard analysis and synthesis methods to be applicable. Hence, there is a need to reduce the complexity of models. In this thesis, techniques for red...

This paper describes the LPVTools software suite developed by MUSYN Inc. LPVTools is a MATLAB toolbox for simulation, analysis, and design of parameter dependent control systems using the Linear Parameter-Varying (LPV) framework. LPVTools contains data structures to represent both LFT and gridded (Jacobian-linearization) types of LPV systems. In addition it contains a collection of functions an...