badi’ iyaat – created as a new technique in a period of arabic literature, that is known as the decline era. the study of this technique as a form of poetry in this era, creates a cloud of doubt for naming the period. there have been many poets with thousands of great poems that reflect the prominence of this era not its decline. the writer of this article has studied badi’ iyaat in khazaanat –...

3-Methylcholanthrene (3MC) is an aryl hydrocarbon receptor (AhR) agonist, and it has been reported that 3MC induces estrogenic activity through AhR-estrogen receptor A (ERA) interactions. In this study, we used 3MC and 3,3V,4,4V,5pentachlorobiphenyl (PCB) as prototypical AhR ligands, and both compounds activated estrogen-responsive reporter genes/gene products (cathepsin D) in MCF-7 breast canc...

Oestrogen protects the heart from ischaemic injury. The current study aims to characterise two novel oestrogen receptor (ER) ligands, an ERa agonist ERA-45 and an ERb antagonist ERB-88, and then use them to investigate the roles of ERa and ERb in mediating the cardioprotection by E from ischaemia– reperfusion injury in the rat. The ER ligands were characterised by gene transactivation assay usi...

in terms of time, iranian mystic seyyed jaafar kashfi belongs to the era that is known as the end of the political thought era, from the perspective of decline theory. however, he is one of the great thinkers of the qajar era who in his two books entitled “tohfat al-muluk” and “mizan al-muluk” presented his political thought on the basis of mystical way. the main question in this research is wh...

Methods Data were analysed from ICHF, Kharkov and Kemerovo databases prior to and since commencement of assistance (era A – 2000–2007; era B 2008-2012). Totaly 1772 pediatric surgical cases were analysed. We evaluated differences between era A and era B for: Case volume per year, (+/-SD), 30 day/hospital mortality, case complexity (RACHS-1 model), and RACHS adjusted standardised mortality ratio...

Apoptosis is considered to be a way of eliminating unwanted cells without causing major inflammation. Nevertheless, several lines of evidence show that apoptotic cell-derived antigens can be strong immunogens. The rabies virus glycoprotein G-ERA is an apoptotic molecule. We tested the ability of G-ERA to potentiate a B cell response against an exogenous antigen (influenza hemagglutinin, HA). We...

BACKGROUND This study analyzes factors associated with differences in long-term outcomes after hepatic resection for metastatic colorectal cancer over time. STUDY DESIGN Sixteen-hundred consecutive patients undergoing hepatic resection for metastatic colorectal cancer between 1985 and 2004 were analyzed retrospectively. Patients were grouped into 2 eras according to changes in availability of...

Phytoestrogens exert pleiotropic effects on cellular signaling and show some beneficial effects on estrogen-dependent diseases. However, due to activation/inhibition of the estrogen receptors ERa or ERb, these compounds may induce or inhibit estrogen action and, therefore, have the potential to disrupt estrogen signaling. We performed a comprehensive analysis and potency comparison of phytoestr...

Environmental estrogen mimics, including metalloestrogens that can activate estrogen receptor-alpha (ERa), may contribute to breast cancer risk. However, the underlying mechanisms through which these molecular mimics activate the ERa are generally poorly understood. With concern to this important question, we investigated whether intracellular calcium may mediate the cross-talk between signalin...

We have shown that PBHs can be formed in the matter-dominated era if gravity is described by Brans-Dicke theory. Considering an early matterdominated era in between inflation and reheating, we found that the PBHs which are formed during this era lives longer than the standard case where PBHs are formed in early radiation-dominated era. Thus in comparison with stanard scenario more number of PBH...