Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports demonstrated that S1P receptors are expressed in the EVT cells and S1P could regulate migration and function of trophoblast cells via S1P receptors. However, little is known about roles of S1P in the invasion of EVT cells. Our study was performed to investigate ...

The simultaneous publication of 3 randomized control trials comparing intravenous thrombolysis therapy to the endovas-cular treatment (EVT) of acute ischemic stroke might have lead to the erroneous conclusion that EVT has no place in the management of acute ischemic stroke. However, careful analysis of these studies shows that these reports have shortcomings because of changes in imaging and de...

BACKGROUNDS/AIMS Preeclampsia was characterized by excessive thrombin generation in placentas and previous researches showed that thrombin could enhance soluble Fms-like tyrosine kinase 1 (sFlt-1) expression in first trimester trophoblasts. However, the detailed mechanism for the sFlt-1 over-production induced by thrombin was largely unknown. The purpose of this study was to explore the possibl...

Background: The management of dehiscence esophageal anastomosis is challenging and requires a multidisciplinary approach. Endoluminal vacuum therapy (EVT) has shown promising results. Case Presentation: Herein we present the data two cases with atresia who developed anastomotic leakage, during 2021-2022, underwent EVT. first case had 60% anastomosis, leak repair was performed followed by EVT pl...

Introduction: Recent randomised controlled trials have demonstrated the benefit of intracranial endovascular thrombectomy (EVT) in acute ischaemic stroke with large vessel occlusion, and number EVTs has increased rapidly. There are no data on how to treat concomitant extracranial carotid artery stenosis after EVT. The aim this study was evaluate outcome patients treated endarterectomy (CEA) suc...

This paper aims to study the forecasting capabilities of several models under Markov regime-switching (MRS) and extreme value theory (EVT) frameworks applied daily electricity prices in New Zealand market. The MRS this include up five regimes, with time-varying transition probabilities incorporation external market variables. We apply Hamilton's filter maximum likelihood estimation for paramete...

The aim of this study was to clarify the general status and historical transition of endovascular therapy (EVT) of acute stroke with major vessel occlusion before approval of mechanical thrombectomy devices in Japan from January 2005 to December 2009. We extracted 1,409 acute ischemic stroke patients receiving EVT (513 women, 69.8±11.8 years) from two nationwide registry studies, the Japanese R...