Although holonic manufacturing systems (HMS) have been recognized as a paradigm to cope with changes in manufacturing environment based on a flexible architecture, several characteristics of HMS such as re-configurability have not been characterized quantitatively. To realize these advantages, more concrete mechanisms or methodologies need to be developed. The objectives of this paper are to pr...

Transcription factor (TF) binding and histone modification (HM) are important for the precise control of gene expression. Hence, we constructed statistical models to relate these to gene expression levels in mouse embryonic stem cells. While both TF binding and HMs are highly 'predictive' of gene expression levels (in a statistical, but perhaps not strictly mechanistic, sense), we find they sho...

In metazoans, each cell type follows a characteristic, spatio-temporally regulated DNA replication program. Histone modifications (HMs) and chromatin binding proteins (CBPs) are fundamental for a faithful progression and completion of this process. However, no individual HM is strictly indispensable for origin function, suggesting that HMs may act combinatorially in analogy to the histone code ...

Many cities have been built along large rivers. The rivers can provide a source of drinking water, act as receiving water for treated effluent, provide navigation for shipping, and other beneficial uses. However, the city must also be protected from flooding due to the close proximity to the river. Hydrologic analysis plays a crucial role in the development of plans for protecting a river city....

Single-cell recording, electrolytic lesion and electrical stimulation studies have indicated that the pontomedullary reticular formation (PMRF) plays a role in head movement (HM) control. However, recent studies utilizing excitotoxin lesions of the PMRF have reported no effect on HM. In the present study, we have examined the acute and chronic motor effects of injecting ibotenic acid (IBO) into...

PURPOSE To assess the clinical features and distribution of brain metastases (BMs) of small cell lung cancer (SCLC) in the hippocampal and perihippocampal region, with the purpose of exploring the viability of hippocampal-sparing whole-brain radiation therapy (HS-WBRT) on reducing neurocognitive deficits. METHODS This was a retrospective analysis of the clinical characteristics and patterns o...