We previously demonstrated that bovine subcutaneous preadipocytes promote adipogenic gene expression in muscle satellite cells in a co-culture system. Herein we hypothesize that saturated fatty acids would promote adipogenic/lipogenic gene expression, whereas mono- and polyunsaturated fatty acids would have the opposite effect. Bovine semimembranosus satellite cells (BSC) and intramuscular prea...

BACKGROUND Two serologic assays, Aspergillus latex agglutination testing (LA) and plasma (1-->3)-beta-D-glucan (BDG) measurement, are used when invasive pulmonary aspergillosis (IPA) is suspected. Despite the high specificity of these assays, false-positive results are frequent for neutropenic patients. This study was conducted to evaluate the efficacy of LA and BDG and to investigate the cause...

The aim of this study was to investigate the value of serum Galactomannan (GM) detection for the early diagnosis of Invasive Pulmonary Aspergillosis (IPA) in children as a reference for clinical diagnosis and treatment. A total of 80 high-risk children with IPA were selected (including three confirmed cases, 20 clinically diagnosed cases, 25 suspected cases, and 32 non-IPA patients) for the det...

Thecontinuous Constrained Optimization Problem (COP) often occurs in industrial applications. In this study, we compare three novel algorithms developed for solving the COP.The first approach consists of an Interval Partitioning Algorithm (IPA) that is exhaustive in covering the whole feasible space. IPA has the capability of discarding sub-spaces that are sub-optimal and/or infeasible, similar...

The immunoperoxidase antibody (IPA) technique was used to develop two new tests for serodiagnosis of respiratory syncytial virus infections: a microneutralization test based on the reduction of the number of infected cells and an IPA test for determination of virus-specific immunoglobulin G (IgG). Neutralizing antibody was determined both in the presence and absence of complement. In a group of...

The carbon aerogels prepared by a new method through gelation and supercritical drying in isopropanol were characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy, and a surface area analyzer. Their chemical structure, morphology, and pore structure are discussed. We found that all of these carbon aerogel (CA-IPA) samples have almost the same carbon and oxygen elem...

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immunocompromised humans caused by the ubiquitous environmental mold Aspergillus. Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple ...

we report an unusual case of co?infection of invasive pulmonary aspergillosis (ipa) and fusarial skin infection in a patient with classic pyoderma gangrenosum with unknown causes, which were previously controlled with oral prednisolone, cyclosporine. the diagnosis was made on direct microscopy and culture of endobronchial washing, bronchoalveolar lavage and skin lesion biopsy. the treatment fai...

19 Invasive pulmonary aspergillosis (IPA) is a life threatening disease of 20 immunocompromised patients that requires aggressive therapy. Detection and monitoring 21 therapeutic response during IPA is complex and current molecular diagnostics are not 22 suitably robust. Here, we explored proteomic profiles of bronchoalveolar lavage fluid 23 (BALF) specimens from a persistently neutropenic rabb...

BACKGROUND Invasive pulmonary aspergillosis (IPA) is a significant problem in patients with chemotherapy-induced prolonged neutropenia. Because pulmonary deposition of conidia is the first step in developing IPA, we hypothesized that inhalation of liposomal amphotericin B would prevent IPA. METHODS We performed a randomized, placebo-controlled trial of patients with hematologic disease with e...