There is an increasing interest in developing Phase Change Memory (PCM) based main memory systems. In order to retain the latency benefits of DRAM, such systems typically have a small DRAM buffer as a part of the main memory. However, for these systems to be widely adopted, limitations of PCM such as low write endurance and expensive writes need to be addressed. In this paper, we propose PCMawa...

Abstruct-Research and development of coherent optical fiber communications have been accelerated mainly because of the possibility of receiver sensitivity improvement reaching 20 dB, and partly because of the possibility of frequency-division multiplexing (FDM) with very fine frequency separation. In this paper, recent advances in the research on coherent optical fiber communication systems are...

Use of a phase change material (PCM)-based heat sink in transient thermal management of plastic quad flat package (QFP) electronic devices was investigated experimentally and numerically. Results show that increased power inputs enhance the melting rate as well as the thermal performance of the PCM-based heat sinks until the PCM is fully melted. A three-dimensional computational fluid dynamics ...

Cultured corneal epithelial cells release a factor(s) that stimulates trigeminal neurons to form neurites in vitro. To characterize this trophic effect, conditioned media (serum free, supplemented) from cultures for corneal epithelium, stromal fibroblasts, and endothelium were studied further. Only epithelial conditioned medium (PCM) prolonged neuronal survival and induced neurite outgrowth. Th...

Joubert syndrome (JS) is a developmental brain disorder characterized by cerebellar vermis hypoplasia, abnormal eye movement, ataxia and mental retardation. Mutations in CEP290 mutations are responsible for the cerebello-oculo-renal subtype of JS that includes kidney cysts and retinal degeneration, two phenotypes commonly linked to ciliopathies. CEP290 mutations are also associated with Meckel-...

The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation s...

For several decades, computer’s memory has been volatile. High speed memories such as DRAM and SRAM have been used as main memory and cache memory respectively. Magnetic disks are used as the persistent secondary storage devices. The present DRAM based main memory has reached its energy limits. Due to the advent of nonvolatile memories like PCM, MRAM, RRAM, FeRAM and Flash, there is growing int...

Centrosomes consist of a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Proteins that contain a Pericentrin/AKAP450 centrosomal targeting (PACT) domain have been implicated in recruiting several proteins to the PCM. We show that the only PACT domain protein in Drosophila (the Drosophila pericentrin-like protein [D-PLP]) is associated with both the centrioles and th...

Phase change memory (PCM) as a newly developed storage medium has many attractive properties such as non-volatility, byte addressability, high density and low energy consumption. Thus, PCM can be used to build non-volatile main memory databases. However, PCM’s long write latency and high write energy bring challenges to PCM-based memory systems. In this paper, we propose an improvement over the...

Nowadays, many applications use spatial data for instance-location information, so storing spatial data is important. We suggest using R -Tree over PCM. Our objective is to design a PCM-sensitive R -Tree that can store spatial data as well as improve the endurance problem. Initially, we examine how R -Tree causes endurance problems in PCM, and we then optimize it for PCM. We propose doubling th...