Cis-diamminedichloridoplatinum(II) (CDDP), commonly referred to as cisplatin, is a chemotherapeutic drug used for the treatment of a wide range of solid cancers. CDDP is a relatively poor inducer of immunogenic cell death (ICD), a cell death modality that converts dying cells into a tumor vaccine, stimulating an immune response against residual cancer cells that permits long-lasting immunity an...

Reticulons (RTNs) are a relatively new eukaryotic gene family with unknown functions but broad expression and peculiar topological features. RTNs are widely distributed in plants, yeast and animals and are characterized by a approximately 200-amino-acid C-terminal domain, including two long hydrophobic sequences. Nogo/RTN4 can inhibit neurite growth from the cell surface via specific receptors,...

A new stochastic process was developed by considering the internal performance of macro-states in which sojourn time each one is phase-type distributed depending on time. The stationary distribution calculated through matrix-algorithmic methods and multiple interesting measures were worked out. number visits to a determine macro-state analyzed from respective differential equations Laplace tran...

Random Telegraph Noise (RTN) is a stochastic phenomenon which leads to characteristic variations in electronic devices. Finding features of this signal may result its modeling and eventually removing the noise device. Measuring accompanied by some therefore we require method improve Signal Ratio (SNR). As result, extraction an accurate RTN remarkable challenge. Empirical Mode Decomposition (EMD...

Cytoplasmic dynein is a AAA ATPase with a ring structure at each head.) presented his group's efforts to understand how organelle shapes are formed and maintained. The fi ndings identify two protein families that create tubules out of ER membrane. A sphere is the most stable membrane shape; deformations that increase membrane curvature cost energy and must be actively stabilized. Rapoport and c...

تصویربرداری مقطع‌نگاری نوترونی یکی از کاربردهای مدرن رآکتورهای تحقیقاتی در سرتاسر جهان به‌شمار می‌رود. تلفیق قابلیت نمایش سه‌بعدی با ویژگی‌های منحصر به فرد برهم‌کنش نوترون مواد، می‌تواند اطلاعات بسیار ارزشمندی ساختار داخلی مواد و تجهیزات را اختیار محققین قرار ‌دهد. این تحقیق، تأثیر هندسه داده‌برداری تجربی روش بازسازی تصویر بر کیفیت تصاویر سامانه رآکتور تهران براساس شاخص وضوح میزان تولید نویز مو...

Earlier studies showed that positive modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors enhance synaptic responses and facilitate synaptic plasticity. Those studies focused mainly on hippocampal functions. However, AMPA receptors have regionally distinct subunit compositions and thus potencies and efficacies of modulators may vary across the brain. The prese...

Charge trapping plays an important role for the reliability of electronic devices and manifests itself in various phenomena like bias temperature instability (BTI), random telegraph noise (RTN), hysteresis or trap-assisted tunneling (TAT). In this work we present Comphy v3.0, open source physical framework modeling these effects a unified fashion using nonradiative multiphonon theory on one-dim...

We studied the membrane transporters that mediate intracellular pH (pH(i)) recovery from acidification in brainstem neurons from chemosensitive regions of neonatal rats. Individual neurons within brainstem slices from the retrotrapezoid nucleus (RTN), the nucleus tractus solitarii (NTS), and the locus coeruleus (LC) were studied using a pH-sensitive fluorescent dye and fluorescence imaging micr...