toxin, have been commonly used for the treatment of congestive heart failure and other cardiac diseases. In addition to the narrow therapeutic range of the serum digitalis glycosides, their bioavailability is easily affected by kidney or liver failure and the dosing of other medicines. Therefore, it is important to accurately measure the digitalis glycosides in sera from digitalized patients. D...

Modest antidepressant response rates of mood disorders (MD) encourage benzodiazepine (BZD) co-medication with debatable benefit. Adult hippocampal neurogenesis may underlie antidepressant responses, but diazepam co-administration impairs murine neuron maturation and survival in response to fluoxetine. We counted neural progenitor cells (NPCs), mitotic cells, and mature granule neurons post-mort...

We investigate the (unbounded) derived category of a diierential Z-graded category (=DG category). As a rst application, we deduce a 'triangulatedanaloguè (4.3) of a theorem of Freyd's 5, Ex. 5.3 H] and Gabriel's 6, Ch. V] characterizing module categories among abelian categories. After adapting some homological algebra we go on to prove a 'Morita theorem`(8.2) generalizing results of 19] and 2...

abstract: in this paper a control scheme for grid-connected operation mode and the island state of distributed generation is presented. in normal conditions, every inverter dg system in micro-grids to supply a preset power, normally operate in a constant current control mode. when micro-grids removed from the network, dg inverter of each system must recognize the island and change position to v...

The insertion of distributed generator (DG) into distribution systems for performance improvement has been an obvious application. But the choice of DG has been extended to the networked systems as well in the recent years. The penetration level of DG is accelerating due to the liberalization of electricity markets and Technological advances in small generators and energy storage devices. In th...

OBJECTIVE To understand how aquaporin4 (AQP4) and dystroglycan (DG) polarized distribution change and their roles in brain edema formation after traumatic brain injury (TBI). METHODS Brain water content, Evans blue detection, real-time PCR, western blot, and immunofluorescence were used. RESULTS At an early stage of TBI, AQP4 and DG maintained vessel-like pattern in perivascular endfeet; M1...

Disordered gambling (DG) will soon be included along with the substance use disorders in a revised diagnostic category of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 called 'Substance Use and Addictive Disorders'. This was premised in part on the common etiologies of DG and the substance use disorders. Using data from the national community-based Australian Twin Registry, we...

The steady-state brain/plasma distribution ratios of [14C]deoxyglucose ([14C]DG) for hypoglycemic rats previously determined by measurement of DG concentrations in neutralized acid extracts of freeze-blown brain and plasma exceeded those predicted by simulations of kinetics of the DG model. Overestimation of the true size of the precursor pool of [14C]DG for transport and phosphorylation could ...

PURPOSE The aim of this study was to evaluate 99mTc-ethylenedicysteine-glucosamine (EC-DG) for the assessment of tumor growth. METHOD To evaluate whether 99mTc-EC-DG is involved in cell nuclei activity, in vitro thymidine incorporation, and cell-cycle assays of EC-DG were conducted using lung and breast cancer cells. Biodistribution of 99mTc-EC-DG in lung tumor-bearing mice (0.5-4 hours, 1 Ci...

2-Deoxyglucose (2-DG) is a toxic glucose analog. To identify genes involved in 2-DG toxicity in Schizosaccharomyces pombe, we screened a wild-type overexpression library for genes which render cells 2-DG resistant. A gene we termed odr1, encoding an uncharacterized hydrolase, led to strong resistance and altered invertase expression when overexpressed. We speculate that Odr1 neutralizes the tox...