Tranexamic acid has proven to be an effective treatment for heavy menstrual bleeding (HMB). It reduces menstrual blood loss (MBL) by 26%-60% and is significantly more effective than placebo, nonsteroidal anti-inflammatory drugs, oral cyclical luteal phase progestins, or oral etamsylate, while the levonorgestrel-releasing intrauterine system reduces MBL more than tranexamic acid. Other treatment...

Porphobilinogen deaminase (PBGD) catalyzes the formation of 1-hydroxymethylbilane (HMB), a crucial intermediate in tetrapyrrole biosynthesis, through a step-wise polymerization of four molecules of porphobilinogen (PBG), using a unique dipyrromethane (DPM) cofactor. Structural and biochemical studies have suggested residues with catalytic importance, but their specific role in the mechanism and...

The aim of this study was to verify the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical capacity, body composition and the value of biochemical parameters in highly-trained combat sports athletes. Forty-two males highly-trained in combat sports were subjected to 12 weeks of supplementation with HMB and a placebo in a randomized, placebo controlled, double-blind cros...

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, virus-triggered immune disease. Hypersensitivity to mosquito bite (HMB), a presentation of Chronic Active Epstein-Barr Virus infection (CAEBV), may progress to HLH. This study aimed to investigate the immunologic difference between the HMB episodes and the HLH episodes associated with EBV infection. Immunologic changes of immunoglo...

this study was conducted to investigate the effect of aflatoxin b1 (afb1) on performance and egg quality in broiler breeders and the abatement of its deteriorative effect through its counteraction with herbal mycotoxin binder (hmb). thirty-six, 28-wk-old broiler breeder hens were allotted to one of the three treatments of: (1) basal diet (control),(2) control plus 500 μg kg-1 afb1 and (3) contr...

Human blood Vγ9/Vδ2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection. Studying their interaction in vitro and relating these findings to in vivo observations in patients may therefore provide crucial insight into inflammatory events. Our present data demonstrate that Vγ9/Vδ2 T cells provide potent survival s...

BACKGROUND The purpose of this study was to examine if L-leucine (Leu), β-hydroxy-β-methylbutyrate (HMB), or creatine monohydrate (Crea) prevented potential atrophic effects of myostatin (MSTN) on differentiated C2C12 myotubes. METHODS After four days of differentiation, myotubes were treated with MSTN (10 ng/ml) for two additional days and four treatment groups were studied: 1) 3x per day 10...

Introduction: Breast milk is a liquid secreted by the mother’s breast glands and useful for baby. The World Health Organization (WHO) American Academy of Pediatrics (AAP) stated that best alternative donor human (DHM). Until now, there no HMB in Indonesia. This study aims to determine relationship between knowledge attitudes with behavior health workers regarding acceptance Human Milk Banks (HM...

The inflammatory response to muscle-damaging exercise requires monocyte mobilization and adhesion. Complement receptor type 3 (CR3) and macrophage inflammatory protein (MIP)-1β enables monocyte recruitment, adhesion, and subsequent infiltration into damaged muscle tissue. The purpose of this study was to examine the effects of cold water immersion (CWI) and/or β-hydroxy-β-methylbutyrate free ac...

The radial stator of three-pole radial-axial hybrid magnetic bearings (HMB) has three magnetic poles and the three magnetic poles are driven by a three-phase converter, so the three-pole radial-axial HMB has the advantages of compact structure, low cost, low power consumption and so on. However, as the sum of three-phase current is zero and the three radial magnetic poles are asymmetric, the re...