نتایج جستجو برای: نانوزیولیت 4a
تعداد نتایج: 6044 فیلتر نتایج به سال:
To locate the genes controlling adaptability in bread wheat using AMMI (additive main effect and multiplicative interaction) model, twenty-one substitution lines derived from the parents Chinese Spring (recipient) and Chayan (donor) were used in a randomized complete block design with three replications in three different environments in the Agricultural College of Razi University, Kermanshah, ...
An improved and scalable synthesis of the unsubstituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene framework facilitates access to the previously unreported parent dipyrrin HCl salt, as well as 4,4-dichloro-4-bora-3a,4a-diaza-s-indacene.
از آنجایی که در آینده ای نزدیک سوخت های مایع هیدروکربنی سهم عمده ای از بخش حمل و نقل را به خود اختصاص خواهند داد؛ متانول می تواند، به عنوان سوختی بسیار پاک تر از سوخت های معمول بر پایه نفت، به شکل بالقوه ای مورد استفاده قرار گیرد. بنابراین توسعه فرآیند سنتز متانول در جهت بهبود فرآوری متانول توجه روز افزونی را به خود جلب نموده است. در این پایان نامه به شرح مدل ریاضی پایای فرآیند سنتز متانول در...
Cholinesterase Inhibition Activity and Docking Simulation Study of Coumarin Mannich Base Derivatives
Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two major forms of cholinesterases (ChEs) is considered as the common approach for the treatment of Alzheimer's disease (AD). The present study was done to explore the anticholinesterase inhibition property of coumarin Mannich base derivatives. A series of cumarin Manich bases were synthesized (4a-h) through one-po...
Rapid emergence of drug resistance in Mycobacterium tuberculosis (MTB) is a major health concern and demands the development of novel adjunct immunotherapeutic agents capable of modulating the host immune responses in order to control the pathogen. In the present study, we sought to investigate the immunomodulatory effects of G1-4A, a polysaccharide derived from the Indian medicinal plant Tinos...
The hepatitis C virus (HCV) non-structural (NS) 3/4A protein complex inhibits the retinoic acid inducible gene I (RIG-I) pathway by proteolytically cleaving mitochondria-associated CARD-containing adaptor protein Cardif, and this leads to reduced production of beta interferon (IFN-beta). This study examined the expression of CCL5 (regulated upon activation, normal T-cell expressed and secreted,...
p-Hydroxyphenylacetate hydroxylase (HPAH) from Acinetobacter baumannii catalyzes the hydroxylation of p-hydroxyphenylacetate (HPA) to form 3,4-dihydroxyphenylacetate (DHPA). The enzyme system is composed of two proteins: an FMN reductase (C1) and an oxygenase that uses FMNH- (C2). We report detailed transient kinetics studies at 4 degrees C of the reaction mechanism of C2.C2 binds rapidly and t...
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are described. ITMN-191 inhibited a reference genotype 1 NS3/4A protein in a time-dependent fashion, a hallmark of an inhibitor with a two-step binding mech...
Eukaryotic initiation factor 4A (eIF-4A) is one of the factors required for the binding of mRNA to 40S ribosomal subunits (1). Nielsen et al. have reported a mouse eIF-4A cDNA encoding a protein of 390 arnino acid residues (2). Subsequently they have cloned two genes encoding eIF-4A variants (eIF-4AI and eIF-4AII) whose arnino acid sequences are 91% identical (3). The genes encoding the two pro...
Here we lay the ground work for the detection of hepatitis C viral NS3-4A protease exploiting peptide-protein interaction. The NS3-4A protease is inhibited by N-terminal cleavage products. Our approach is based on the formation of a self-assembled monolayer (SAM) of a ferrocene amino acid derivative on an electrode surface. A short NS3-4A specific inhibitory peptide (Asp-Glu-Ile-Val-Pro-Nva) wa...
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