Oculocutaneous albinism (OCA) is an autosomal recessive disorder characterized by either complete lack of or a reduction in melanin biosynthesis in the skin, hair, and eyes. OCA1, the most common and severe type, is caused by mutations in the tyrosinase (TYR) gene. In this study, we report a Chinese family with two members affected by OCA. Blood samples were collected from all family members. G...

results out of 140 samples of oca, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. out of 70 malignant samples 25 (36.0%) were hpv-16 positive. 2.8% of the tissue samples of the control group were positive for hpv-16. conclusions these results show a feasible role of hpv-16 in the carcinogenesis of oca. according to these results, infection with hpv ...

BACKGROUND Transplantation of fresh osteochondral allografts (OCAs) is an attractive treatment option for symptomatic articular cartilage lesions in young, healthy patients. Because the lack of OCA bone integration can be a cause of treatment failure, methods for speeding and enhancing OCA bone integration to mitigate this potential complication are highly desirable. PURPOSE To determine if a...

Se analiza la trayectoria plenomedieval de antigua sede episcopal Oca, abandonada tras invasión islámica 711. Nos basamos en el análisis documental, principalmente los fondos catedralicios, emilianenses y, como novedad, inédito cartulario Froncea. Oca nunca recuperó una función relevante organigrama diocesano, perjudicada por creación gran diócesis castellana centrada Burgos y enajenación a San...

Primary biliary cholangitis (PBC), previously known as primary biliary "cirrhosis", is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destruction of small bile duct epithelial cells leading to cholestasis and cirrhosis. Surprisingly, while immune modulators have not been effective in the treatment of PBC, supplementatio...