To explore the association of TNF-α-308 and IFNγ +874 genetic polymorphisms with type 2 diabetes mellitus (DM) in Egyptian cases. Participants included 207 cases with type 2 DM, 93 males and 114 females. Their mean age was 57 years. They were compared to a control group of 212 healthy unrelated subjects from the same locality. DNA was amplified using PCR with sequence specific primers for detec...

Asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. The role of tumor necrosis factor-α (TNF-α) in asthma is unclear in Pakistani population. The aim of this study was to assess the relationship between TNF-α-308 polymorphism and asthma. Polymorphism of TNF-α (G-308-A locus; rs 1800629) in 329 asthm...

INTRODUCTION The etiopathogenesis of basal cell carcinoma (BCC) is multifactorial. The TNF-α gene seems to be an interesting gene candidate for BCC susceptibility because of the proinflammatory and immunosuppressive properties of its product. The aim of the study was to assess the frequency of -308 G/A and -238 G/A gene polymorphisms in the TNF-α gene and serum levels of cytokine in patients wi...

Distribution and transport processes of marine particulate matter off Cape Blanc (NW-Africa): results from vertical camera profiles N. Nowald, G. Karakas, V. Ratmeyer, G. Fischer, R. Schlitzer, R. A. Davenport, and G. Wefer University of Bremen, Department of Geosciences, Klagenfurterstrasse, 28359 Bremen Alfred Wegener Institute Foundation for Polar and Marine Research, Bürgermeister-Smidt-Str...

http://www.sciencemag.org/cgi/content/full/308/5729/1801 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1106215/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.s...

Objective: Tumour necrosis factor (TNF)-alpha, a prototype proinflammatory cytokine, has been implicated as an important pathogenic mediator in a variety of liver conditions. Some genetic polymorphisms in the human TNF-alpha promoter region, such as the G-A transitions -308 and – 238, have been shown to influence TNF-alpha expression in chronic hepatitis C virus infection. Aim of the work: The ...

www.sciencemag.org (this information is current as of December 8, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/308/5726/1260c version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/308/5726/1260c/DC1 can be ...