The effect of specific anti-I-J reagents on macrophage-T cell interactions was studied in an in vitro antibody response to burro erythrocytes. Macrophages were prepared from the spleens of F1 hybrid mice whose parental strains differed at the I-J subregion. Two F1 hybrids were used for these experiments, [B10.A(3R) X B10.A(5R)]F1 and [B10.S(9R) X B10.HTT]F1. F1 macrophages responded equally wel...

Previous studies have shown that mucosal application of interleukin-12 (IL-12) can stimulate elevated secretory immunoglobulin A (IgA) responses. Since possible exposure to plague is via Yersinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic immune systems may offer an added benefit for protective immunity. Two bicistronic plasmids were constructed...

This paper presents a longitudinal analysis of the extent to which age affects F0 and formant frequencies. Five speakers at two time intervals showed a clear effect for F0 and F1 but no systematic effects for F2 or F3. In two speakers for which recordings were available in successive years over a 50 year period, results showed with increasing age a decrease in both F0 and F1 for a female speake...

To investigate the possible enhancing effect of the H-2z haplotype of the New Zealand White (NZW) strain on the production of autoantibodies and renal disease observed in B/W F1 mice, we developed the ZWD/8 strain, a NZW congenic line carrying the H-2d haplotype, produced (NZB X ZWD/8)F1 (B/WD8 F1) mice, and examined the difference in several immunological abnormalities between the B/W F1 (H-2d...

Information was sought on whether B cells undergo abnormal differentiation in F1 leads to parent chimeras (irradiated parental-strain mice reconstituted with F1-hybrid bone marrow cells). As assessed by collaborative responses to sheep erythrocytes in vivo, three different types of T cells restricted to interaction with strain a H-2 determinants were shown to collaborate as effectively with het...

This article describes how a mixture of two densities, f0 and f1, may be decomposed into a different mixture consisting of three densities. These new densities, f+, f−, and f=, summarize differences between f0 and f1: f+ is high in areas of excess of f1 compared to f0; f− represents deficiency of f1 compared to f0 in the same way; f= represents commonality between f1 and f0. The supports of f+ ...