نتایج جستجو برای: پلیمر plga

تعداد نتایج: 7972  

Journal: :Acta biomaterialia 2009
Xuetao Shi Yingjun Wang Li Ren Naru Zhao Yihong Gong Dong-An Wang

Tissue engineering scaffolds with a micro- or nanoporous structure and able to deliver special drugs have already been confirmed to be effective in bone repair. In this paper, we first evaluated the biomineralization properties and drug release properties of a novel mesoporous silica-hydroxyapatite composite material (HMS-HA) which was used as drug vehicle and filler for polymer matrices. Biomi...

2016
Delphine Guldner Julianne K. Hwang Maria Clara D. Cardieri Meaghan Eren Parissa Ziaei M. Grant Norton Cleverson D. Souza

Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) have been considerably studied as a promising biodegradable delivery system to induce effective immune responses and to improve stability, safety, and cost effectiveness of vaccines. The study aimed at evaluating early inflammatory effects and cellular safety of PLGA NPs, co-encapsulating ovalbumin (PLGA/OVA NPs), as a model antigen and th...

Journal: :Journal of biomaterials science. Polymer edition 2012
Chun-Yang Wang Jun-Jian Liu Cun-Yi Fan Xiu-Mei Mo Hong-Jiang Ruan Feng-Feng Li

Recent bioengineering strategies for peripheral nerve regeneration have been focusing on the development of alternative treatments for nerve repair. In this study, we incorporated nerve growth factor (NGF) into aligned core-shell nanofibres by coaxial electrospinning, and reeled the scaffold into aligned fibrous nerve guidance conduits (NGCs) for nerve regeneration study. This aligned PLGA/NGF...

2013
I-Chun Tai Yin-Chih Fu Chih-Kuang Wang Je-Ken Chang Mei-Ling Ho

Statins are used clinically for reduction of cholesterol synthesis to prevent cardiovascular disease. Previous in vitro and in vivo studies have shown that statins stimulate bone formation. However, orally administered statins may be degraded during first-pass metabolism in the liver. This study aimed to prevent this degradation by developing a locally administered formulation of simvastatin th...

2013
Eun Jin Seo Il Ho Jang Eun Kyoung Do Hyo Cheon Cheon Soon Chul Heo Yang Woo Kwon Geun Ok Jeong Ba Reun Kim Jae Ho Kim

Reprogramming of somatic cells to pluripotent cells requires the introduction of factors driving fate switches. Viral delivery has been the most efficient method for generation of induced pluripotent stem cells. Transfection, which precedes virus production, is a commonly-used process for delivery of nucleic acids into cells. The aim of this study is to evaluate the efficiency of PLGA/ bPEI nan...

2013
Anuradha Subramanian Uma Maheswari Krishnan Swaminathan Sethuraman

Electroactive polymers have applications in tissue engineering as a physical template for cell adhesion and carry electrical signals to improve tissue regeneration. Present study demonstrated the biocompatibility and biodegradability of poly(lactide-co-glycolide)-poly(3-hexylthiophene) (PLGA-PHT) blend electrospun scaffolds in a subcutaneous rat model. The biocompatibility of PLGA-undoped PHT, ...

2015
Shaoping Sun Na Liang Hiromitsu Yamamoto Yoshiaki Kawashima Fude Cui Pengfei Yan

This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanopartic...

2017
Nopparuj Soomherun Narumol Kreua-Ongarjnukool Sorayouth Chumnanvej Saowapa Thumsing

Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro. This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation...

Journal: :Journal Of Mechanical Engineering, Science, And Innovation 2022

Nanopartikel poly (lactic-co-glycolic acid) (PLGA) adalah salah satu nanopartikel polimer biodegradable yang paling efektif dalam sistem penghantaran obat. Penelitian ini dilakukan untuk mengkaji perkembangan penelitian PLGA obat melalui pendekatan bibliometrik dengan analisis pemetaan menggunakan VOSviewer. Data artikel diperoleh dari database Google Scholar software Publish or Perish. Kata ku...

Mahdi Ghorbani, Maryam Hashemi Mohammad Hossein Bahreyni Toosi Mohammad Ramezani Nima Hamzian,

Introduction: To increase the radiation therapy efficiency, two approaches have been employed which include increasing the dose delivery or modifying the biological response to ionizing radiation. This study aimed to modify the biological response to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Materials and Methods:</str...

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