Fosfomycin is a naturally occurring antibacterial agent with a broad spectrum of antimicrobial activity against both Grampositive and Gram-negative bacteria (1). Recently, a fosfomycin resistance gene, fosA3, was detected in Escherichia coli and Klebsiella pneumoniae isolates (2–6). This gene is normally plasmid mediated, surrounded by IS26 transposase genes, and often detectable in CTX-M-produ...

Background & Aims: One of the most common causes of bacterial resistance to beta-lactam antibiotics is beta-lactamase producing. The aim of this study was to compare the antibiotic resistance of urinary Escherichia coli (E. coli) isolates producing CTX-M and TEM type beta-lactamases, and to determine the strains with co-resistance to multiple antibiotics in Mashhad, Iran. Methods: E. coli b...

conclusions the results indicate that the rates of esbls are high in urine e. coli and k. pneumoniae isolates from tehran hospitals. also this study indicates that the urine isolates from male patients are significantly more resistant than the female isolates. materials and methods a total of 190 e. coli and k. pneumoniae isolates were collected from patients’ urine samples in hospitals from te...

background: there is a growing concern on the impact of the presence of extended-spectrum β-lactamase (esbl) producing escherichia coli isolated from animals on public health. objectives: the aim of this study was to investigate the presence of three classes of esbl genes in e. coli isolates from sheep and broilers at a slaughter in urmia region, iran. methods: a total of 111 e. coli isolates w...

Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria are a common cause of healthcare and community-associated infections worldwide. The distribution of such isolates in the environment and their presence in fish as a result of sewage contamination is not well-studied. Here we examined fish and environmental samples from Mwanza city for the presence of ESBL-producing bacteria. From 196 fi...

OBJECTIVES Knowledge about the regulatory mechanisms of CTX-M β-lactamase-encoding genes in Escherichia coli is limited. The objectives of this study were to determine the growth response of CTX-M-1-producing E. coli exposed to cefotaxime and to investigate how blaCTX-M-1 expression at mRNA and protein levels is influenced by cefotaxime concentration, growth phase and gene location (chromosome ...

Escherichia coli isolates from various sources 2018 to 2019 were included in the study. Mcr-1 genes found two of 105 animal strains (2%) and seven 928 human (0.8%). All mcr-1-positive showed a low level resistance colistin (MIC ranged 4 8 µg/ml). Both isolated animals remained sensitive betalactam antibiotics did not contain beta-lactamase genes. Beta-lactamases absent only one humans. Four res...