نتایج جستجو برای: کارت atm
تعداد نتایج: 15299 فیلتر نتایج به سال:
با توسعه سریع علم و تکنولوژی، توانایی های فناوری اطلاعات به گونه ای قابل ملاحظه در حال افزایش است. از آنجا که فناوری اطلاعات اثبات کرده که می تواند عملکرد زنجیره تامین را بهبود بخشد، سرمایه گذاری در به کار گیری فناوری اطلاعات افزایش یافته است. با افزایش اطلاع عموم از منافع به کارگیری فناوری اطلاعات، این سوال مطرح می شود که چگونه به کارگیری فناوری اطلاعات بر عملکرد زنجیره تاثیر خواهد گذاشت. مطال...
Lung cancer is the leading cause of cancer-related mortality in the USA and worldwide, and of the estimated 1.2 million new cases of lung cancer diagnosed every year, over 30% are lung adenocarcinomas. The backbone of 1st-line systemic therapy in the metastatic setting, in the absence of an actionable oncogenic driver, is platinum-based chemotherapy. ATM and ATR are DNA damage signaling kinases...
The ataxia telangiectasia mutated (ATM) kinase and H2AX histone tumor suppressor proteins are each critical for maintenance of cellular genomic stability and suppression of lymphomas harboring clonal translocations. ATM is the predominant kinase that phosphorylates H2AX in chromatin around DNA double-strand breaks, including along lymphocyte Ag receptor loci cleaved during V(D)J recombination. ...
Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis. MAPK7 has been implicated in numerous types of cancer with pro-survival and pro-growth roles in tumor cells, but its functional rela...
There are ATM nodes from several vendors in the market and some operators even are offering public ATM services. However, in order to really make a breakthrough of ATM we must develop ATM applications which are acceptable also by others than computerwizards. Our paper gives an outline of the ATM evolution from separate nodes to real and practical services utilizing ATM technology. One of the mo...
The ataxia telangiectasia mutated (ATM) checkpoint is the central surveillance system that maintains genome integrity. We found that in the context of childhood sarcoma, mammalian target of rapamycin (mTOR) signaling suppresses ATM by up-regulating miRNAs targeting ATM. Pharmacological inhibition or genetic down-regulation of the mTOR pathway resulted in increase of ATM mRNA and protein both in...
ATM is becoming a widely used technology as a backbone for connecting data networks. An important consideration when analyzing the performance of data traffic over switched networks such as ATM is the routing scheme utilized. The IP layer traditionally handles all routing processes in TCP/IP networks. For ATM, OPNET contains standard models that map IP packet traffic to ATM virtual circuits. Ho...
Oncogenes can induce p53 through a signaling pathway involving p19/Arf. It was recently proposed that oncogenes can also induce DNA damage, and this can induce p53 through the Atm DNA damage pathway. To assess the relative roles of Atm, Arf, and p53 in the suppression of Ras-driven tumors, we examined susceptibility to skin carcinogenesis in 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphor...
There are conflicting reports about the involvement of single nucleotide polymorphisms (SNPs) of the ataxia telangiectasia mutated (ATM) gene with cancer, and the consequences of these SNPs for ATM function remain unclear. We therefore sought to identify SNPs of the ATM gene in pediatric Hodgkin disease (HD) and to analyze ATM function in cells from patients with these SNPs. We have identified ...
BACKGROUND Cell senescence is involved in the process of organ damage and repair; however, the underlying molecular mechanism needs to be further explored. METHODS AND RESULTS Senescence-related genes (ie, p21, p53, and ataxia telangiectasia mutated [ATM]) were shown to be elevated after myocardial infarction (MI) in both mouse and human hearts. Ten- to 12-week-old male wild-type littermates ...
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