Two new bidesmoside triterpenoid saponins which were identifed as 28-O-β-D-xylopyranosyl(1→3)-β-D-xylopyranosyl(1→4)-α-L-rhamnopyranosyl(1→2)-[α-L-rhamno-pyranosyl(1→3)]-β-D-fucopyranosyl gypsogenin 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranosiduronic acid (C1) and 28-O-β-D-xylopyranosyl(1→4)-α-L-rhamnopyranosyl (1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-fucopyranosyl gypsogenin 3-O-β-D-gluco-pyrano...

Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy and safety in humans is largely unknown. This review discusses the benefits and limitations of bitter melon supplementation in the context of epidemic levels of insulin resista...

Background: There is yet a dearth of literature on the antifertility effect of Momordica charantia on the male reproductive system. The aim of this study was to determine the effect of graded oral doses of methanolic seed extract of Momordica charantia on the histology of prostate gland and seminiferous tubules of rats. Methods: Forty male Sprague-Dawley rats, weighing 176±7 g were assi...

insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has affecting several millions of population all over the world. The individual with diabetes has a 25-fold increase in the risk of blindness, a 20-fold increase in the risk of renal failure, a 20-fold increase in the risk of amputation as a result of gangrene and a 2 to 6 fold increas...

Momordica charantia L. (Cucurbitaceae family), medicinal and nutraceutical plant known from Asia, South Africa, America, the Caribbean region, has been acclimatized in Romania since 1990 until now. This plant, cultivated open greenhouses belonging to S.C. HOFIGAL Import Export S.A. studied several projects, among which “Project 160/2014-2017 – MAIA Multifunctional innovative products for safe b...

Pare Plant is a type of horticultural plant originating from the cucurbitaceae family. Bitter gourd contains antioxidants that help suppress inflammatory response and lower glucose levels in diabetes. Cultivation bitter melon by using pruning use NPK fertilizer can increase production yields. Pruning on plants needs to be done order number flowers produced plants. macro nutrient needed able gro...

Diabetes mellitus (DM) is a serious metabolic disorder with micro and macro-vascular complications that result in a significant morbidity and mortality. The present study investigated the effects of Momordica charantia (M. charantia) on histological changes of the aorta and pulmonary trunk in streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randoml...