BACKGROUND Infection with hepatitis E virus (HEV) in immunocompromised patients can lead to severe liver disease. Treatment options for HEV include peginterferon or ribavirin, routinely also used for the treatment of hepatitis C virus (HCV) infection. We determined the prevalence and clinical consequences of HEV in United States (US) based patients who underwent liver transplantation (LT) for c...

BACKGROUND Real use of lung (LT) and heart-lung (HLT) transplantation in pulmonary arterial hypertension (PAH) is unknown. The objectives were to describe the indication of these procedures on PAH treatment in a national cohort of PAH patients, and to analyze the potential improvement of its indication in severe patients. METHODS Eligibility for LT/HLT was assessed for each deceased patient. ...

Human T-lymphotropic virus type-I (HTLV-I)-infected T-cell lines constitutively produce high levels of lymphotoxin (LT). To analyze the mechanisms that lead to the expression of LT in HTLV-I-infected cell lines, we studied regulatory regions of the human LT promoter involved in the activation of the human LT gene. As determined by deletional analysis, sequences between +137 and -116 (relative t...

s | 91 Methods: Forty-five right-handed patients with PD who met the diagnostic criteria in Structured Clinical Interview for DSM-V and twenty-two healthy control were examined by means of MRI at 3 Tesla. We used the FreeSurfer software package to create a three-dimensional model of the cortical surface for estimating the cortical thickness. In order to test the effect of the gene polymorphism ...

The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily through the binding and inactivation of p53 and the retinoblastoma family members. Normal p53 function requires an association with the CREB binding protein (CBP)/p300 coactivators, and a ternary complex containing SV40 LT, p53, and CBP/p300 has been identified previously. In this report, we ...

While specifications and verifications of concurrent systems employ Linear Temporal Logic (LT L), it is increasingly likely that 4 logical consequence in LT L will be used in the description of computations and parallel reasoning. Our paper considers logical 5 consequence in the standard LT L with temporal operations U (until) and N (next). The prime result is an algorithm recognizing 6 consecu...